One dose of Pneumo 23 vaccine contains purified capsular polysaccharides Streptococcus pneumoniae twenty-three serotypes that provoke a severe course of the disease: 1-5 (inclusive), 6B, 7F, 8, 9 (N and V), 10 A, 11A, 12F, 14, 15B, 17F, 18C, 19 (A and F ), 20, 22F, 23F and 33F.

As an additional substance, the preparation contains a phenolic buffer solution.

Release form

The vaccine is contained in individual packaging. In the syringe - one dose of 0.5 ml.

The syringe is packed in a cardboard box.

pharmachologic effect

This tool is a pneumococcal polyvalent vaccine, which is used for prophylactic purposes - to prevent pneumococcal infections of various localizations.

In particular, the vaccine is intended for the prevention of pneumonia, sepsis , . Vaccination Pneumo 23 contributes to the formation in the body of Streptococcus pneumoniae, specific to twenty-three serotypes of bacteria.

After the Pneumo 23 vaccine has been administered once, a person has specific immunity for five years. The tool is widely used in children after reaching the age of two to prevent the development of pneumococcal infection in them.

Pharmacokinetics and pharmacodynamics

No data are available on the pharmacokinetics of this drug.

This tool can be combined with the introduction of vaccines that are aimed at preventing influenza.

Indications for use

The use of Pneumo 23 is indicated to prevent the development pneumococcal infection different localization. Recommended for use by children from the age of two.

The vaccine is recommended for everyone who has an increased risk of infection. Streptococcus pneumoniae. In particular, such a vaccination should be carried out for the elderly, children with a weakened body, who are subject to frequent hospitalization.

People who abuse nicotine and alcohol, those who have weakened immunity, and leakage of cerebrospinal fluid are also at risk of infection.

Contraindications

Do not vaccinate with the drug to people who have a history of a reaction in them after receiving pneumococcal vaccine.

Immunization is not carried out for people suffering from infectious and non-infectious diseases in acute form, hyperthermia. The vaccine should not be administered during a relapse of chronic diseases.

Vaccination is allowed only after the patient has a stable remission, or he fully recovers.

Do not administer the drug to people who have received pneumococcal vaccine over the past three years (with the exception of people at risk, as well as those who received immunosuppressive treatment).

It should be borne in mind that a recent pneumococcal infection is not a contraindication to Pneumo 23 vaccination.

Side effects

After the patient receives Pneumo 23, he may develop some local negative reactions: the appearance of induration, swelling, soreness, hyperemia in the place where the drug was injected.

In most cases, such manifestations are mild and disappear very quickly, and no specific treatment is required for this.

Very rarely (in isolated cases) during the use of Pneumo 23, severe local manifestations may develop, including Arthus phenomenon . All of these side effects go away without further treatment.

In people whose body has a high content of antipneumococcal, hyperthermia can develop, and sometimes, very rarely, body temperature can rise to 39 degrees and above.

There are reports of individual cases of arthralgia, adenopathy, skin rash and anaphylactoid reactions. If these or other undesirable manifestations develop, it is necessary to immediately inform the doctor about it.

Vaccination Pneumo 23, instructions for use (Method and dosage)

The instruction for Pneumo 23 provides that the vaccine is used parenterally. This solution must be administered directly from the syringe into which the product is packaged by the manufacturer.

The drug is administered subcutaneously or intramuscularly. It should be noted that it cannot be administered intravenously.

Be sure to administer this vaccine in a specialized medical institution by a qualified specialist.

Before receiving a dose of the vaccine, the patient must be examined by a specialist. If a person has a feeling of general weakness, hyperthermia, exacerbation of chronic diseases, vaccination should be postponed.

After the remedy has been introduced, the person must be under the supervision of a specialist for 30 minutes. If he develops an anaphylactoid reaction, the patient is treated urgently.

The general scheme for using the vaccine is determined by the doctor. As a rule, at the first vaccination one dose (0.5 ml) of Pneumo 23 is administered.

Revaccination valid after at least three years. When carrying out revaccination, a person should also receive one dose (0.5 ml) of the drug.

Decrease allowable interval (three years) between injections Pneumo 23 people who have an increased likelihood of developing pneumococcal infection, as well as those who have recently received immunosuppressive therapy.

Overdose

Data on overdose of Pneumo 23 were not provided.

Interaction

There is no information on the expressed interaction of Pneumo 23 with other drugs.

If there is a need to immunize with several vaccines at once, including Pneumo 23, it is imperative to ask a specialist for information about their compatibility.

With simultaneous treatment with immunosuppressive drugs, the immune response is reduced.

Terms of sale

You can only buy with a doctor's prescription.

Storage conditions

Storage and transportation of the vaccine can only be carried out in its original packaging, while it is important to adhere to the temperature regime from 2 to 8 degrees.

It is impossible to freeze Pneumo 23.

Best before date

special instructions

This vaccine is especially indicated for people who suffer from sickle cell anemia , as well as persons with asplenia ; those who have recently had a splenectomy or people before a splenectomy.

It should be noted that if the revaccination is carried out earlier than the required time, a person may experience severe local side effects after the injection.

Since there is a possibility of severe side effects (in particular, the Arthus phenomenon), it is necessary to evaluate the benefits of vaccination and take into account all contraindications before administering the drug.

If a person receives immunosuppressive treatment, then the immune response to the introduction of Pneumo 23 may be suppressed.

One dose of the vaccine provides effective protection.

Analogues

Coincidence in the ATX code of the 4th level:

Analogues of this vaccine are drugs, Prevenar 13 .

Only a doctor can choose the most optimal remedy after an individual consultation.

Prevenar 13 or Pneumo 23 - which vaccine is better?

The Prevenar 13 vaccine contains fewer serotypes than Pneumo 23. But reviews often contain information that local side effects are more likely to occur when using Prevenar.

At the same time, Prevenar 13, unlike Pneumo 23, can be administered to children up to two years of age. Which vaccine is better to use for immunizing a child, the attending pediatrician will tell you.

In more detail, the expediency of using these vaccines is described by specialists, for example, Dr. Komarovsky.

children

Vaccination with this agent can be carried out for children from the age of two.

It is important to take into account all contraindications and consult a doctor.

During pregnancy and lactation

It is not recommended to administer the vaccine during the first and second trimesters. But if there are serious indications, immunization can be carried out in the third trimester of pregnancy under the close supervision of a doctor.

If a pregnant woman has been vaccinated, after the administration of the drug, she should be under the supervision of a doctor for at least three hours.

It is acceptable to vaccinate during lactation. There is no need to interrupt

Dosage form:  solution for intramuscular and subcutaneous administration Compound:

One dose of the vaccine (0.5 ml) contains:

Active ingredients : purified capsular polysaccharidesStreptococcus pneumoniae23 serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15V, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F - 25 mcg each.

Excipients:

phenol - preservative ≤ 1.25 mg

sodium chloride - 4.15 mg

sodium hydrogen phosphate dihydrate - 0.065 mg

sodium dihydrophosphate dihydrate - 0.023 mg

water for injection - up to 0.5 ml.

Description:

Transparent colorless liquid.

Pharmacotherapeutic group: MIBP - ATH vaccine:  

J.07 Vaccines

J.07.A.L Vaccine to prevent pneumococcal infection

Pharmacodynamics:

Vaccine Pneumo 23 contains purified polysaccharides of 23 serotypes Streptococcus pneumoniae, which accounts for approximately 90% or more of the serotypes that cause invasive pneumococcal infections in developed and developing countries. The nature of the immune response is T-independent, characterized by low immunogenicity in children under two years of age and the absence of the effect of revaccination after repeated injections.

Specific immunity develops 2-3 weeks after immunization.

In a study on the immunogenicity of the Pneumo 23 vaccine, the overall epidemiological efficacy in preventing infections caused by the serotypes included in the vaccine was 57% (95% confidence interval (CI) - 45-66%).

Efficacy in patients with diabetes mellitus was 84% ​​(95% CI 50-95%), coronary heart disease - 73% (95% CI 23-90%), congestive heart failure - 69% (95% CI 17-88%) , chronic lung diseases - 65% (95% CI 26-83%), anatomical asplenia - 77% (95% CI 14-95%). In alcoholism or cirrhosis, sickle cell anemia, chronic renal failure, lymphoma, leukemia, myeloma, epidemiological efficacy was not determined, since the sample sizes in these groups were small. Efficacy in immunocompetent individuals over 65 years of age was 75% (95% CI 57-85%). Efficacy did not decrease with increasing time after vaccination: 5-8 years after vaccination it was 71% (95% CI 24-89%), and 9 or more years after vaccination it was 80% (95% CI 16-95% ).

Antibody titers ≥ 300 ng / ml (measured by antibody nitrogen) after vaccination were achieved in more than 84% of the examined for 21 serotypes out of 22, of which 100% of the examined - for 16 serotypes and 60% of those vaccinated - for serotype 9N. Moreover, vaccination with serotype 6B stimulated the production of antibodies to serotype 6A: ≥ 2-fold seroconversion was achieved in 80% of non-immune individuals, with a mean increase in antibody titer of 5.4-fold.

This vaccine was ineffective against infections caused by serotypes not included in the vaccine (95% CI of epidemiological effectiveness from -73 to 18%; p~0.15).

Indications:

Specific prophylaxis of pneumococcal pneumonia and generalized pneumococcal infections caused by serotypes Streptococcus pneumoniae presented in the vaccine, in persons at risk from the age of two.

The risk group for diseases includes: persons 65 years and older; people with chronic diseases (eg, cardiovascular disease, lung disease, diabetes mellitus, alcoholism, cirrhosis); persons with a weakened immune system (absence or dysfunction of the spleen, sickle cell anemia, Hodgkin's disease, lymphoma, multiple myeloma, oncohematological diseases, chronic renal failure, nephrotic syndrome, organ transplantation); people with HIV infection (asymptomatic and symptomatic); patients with leakage of cerebrospinal fluid; people who are in special institutions for the care of the elderly or disabled; working in conditions that increase the risk of pneumococcal infections or their complications; who are in organized groups (students, military personnel living in hostels).

Contraindications:

Anaphylactic reaction to any of the components that make up the vaccine or to a previous administration of pneumococcal vaccine;

Acute infectious and non-infectious diseases, exacerbation of chronic diseases.

Pregnancy and lactation:

Due to limited data on the use of the vaccine in pregnant women, its use during pregnancy is not recommended.

It is not known if the vaccine is excreted in breast milk.

The decision to vaccinate women during pregnancy and lactation should be made only on the basis of an assessment of the real risk of pneumococcal infection.

The use of the vaccine is possible only if clearly necessary and in cases where the potential benefit to the mother outweighs the possible risk to the fetus or child.

Dosage and administration:

Pneumo 23 is administered intramuscularly or subcutaneously, intramuscular administration is preferred. Do not enter into the vascular bed. Before insertion, it is necessary to ensure that the needle does not enter a blood vessel by slightly moving the syringe plunger towards itself, which should not lead to blood appearing inside the syringe.

Primary immunization: single injection of 0.5 ml.

Revaccination: single injection of 0.5 ml.

The interval between the previous administration of Pneumo 23 or any other pneumococcal polysaccharide vaccine and the administration of Pneumo 23 must be at least 3 years.

Before use, the vaccine should be kept at room temperature for several minutes after being removed from the refrigerator.

Shake before use.

Unused vaccine residue or medical waste must be destroyed (disposed of) in accordance with national requirements.

Side effects:

Like any biologically active drug, this vaccine may cause adverse reactions in some patients:

Soreness, redness, hardness, or swelling at the injection site. These reactions are moderate and pass quickly; reported the occurrence of peripheral edema of the limb into which the vaccine was introduced;

An increase in body temperature (very rarely exceeding 39 ° C) on the day of vaccination, lasting no more than 24 hours;

In very rare cases, it is possible to develop pronounced local reactions that are reversible and suitable without any consequences; as a rule, these reactions develop in individuals with a high level of anti-pneumococcal antibodies;

In very rare cases, headache, myalgia, malaise and fatigue, lymphadenopathy, arthralgia, rash and allergic reactions - urticaria, Quincke's edema, anaphylactic reaction, including shock, febrile convulsions, inflammation of the subcutaneous tissue at the injection site.

Medical supervision is necessary within 30 minutes after the introduction of the vaccine in the presence of anti-shock therapy.

The patient should be informed about the need to inform the doctor about all cases of adverse reactions, including those not listed in this leaflet.

Overdose:

Not applicable.

Interaction:

Pneumo 23 can be administered simultaneously (on the same day) with other vaccines (with the exception of vaccines for the prevention of tuberculosis) in different parts of the body using different syringes.

The patient should be informed of the need to inform the doctor about any treatment prior to vaccination or coinciding with vaccination.

Special instructions:

When conducting immunosuppressive therapy, the immune response to the vaccine may be reduced. In this case, it is recommended to postpone vaccination until the completion of the course.

However, vaccination of those with chronic immunodeficiency such as HIV infection is recommended even if the immune response may be limited.

Carefully used for blood clotting disorders (hemophilia, thrombocytopenia), as well as in patients undergoing anticoagulant therapy, due to an increased risk of hematomas when administered intramuscularly. Children with hemophilia, due to the risk of bleeding when administered intramuscularly, are vaccinated subcutaneously in an area where the injection site can be pressed against the background of the introduction of clotting factor preparations.

Influence on the ability to drive transport. cf. and fur.:

Studies on the effect of the vaccine on the ability to drive cars and other mechanisms have not been conducted.

In this article, you can read the instructions for using the vaccine drug Pneumo 23. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Pneumo 23 in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Pneumo 23 in the presence of existing structural analogues. The use of vaccination for the treatment and prevention of pneumococcal infection in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Pneumo 23- highly purified polyvalent vaccine. It is a purified polysaccharide of Streptococcus pneumoniae (streptococcus) of 23 serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F. Causes the formation of immunity to the specified serotypes of Streptococcus pneumoniae. Immunity is acquired 10-15 days after a single vaccination and persists for at least 5 years. After the introduction of this vaccine, seroconversion occurs in at least 90% of vaccinated individuals.

Compound

Streptococcus pneumoniae polysaccharides (23 serotypes; 25 mcg of each serotype) + excipients.

Indications

• prevention of pneumococcal infections, especially respiratory tract infections, in individuals at risk, starting from 2 years of age.

Release form

Solution for intramuscular and subcutaneous administration (injections in ampoules or syringes for injection).

Instructions for use and vaccination technique

The vaccine is administered subcutaneously or intramuscularly. Primary vaccination is carried out with one dose of this vaccine once. Revaccinations are carried out every five years. The interval between revaccinations may be shortened in individuals at high risk or in patients receiving immunosuppressants.

Side effect

• weakness;
• slight increase in body temperature;
• chills;
• headache (duration - no more than 24 hours);
• local reactions - redness, slight soreness or induration at the injection site after vaccination.

Contraindications

• a pronounced reaction to the previous administration of the vaccine;
• pneumococcal vaccination or previous pneumococcal infection (caused by one of the serotypes contained in the vaccine) up to 5 years before the planned vaccination with this vaccine.

Use during pregnancy and lactation

Although there is no evidence of adverse effects on the fetus when using the Pneumo 23 vaccine during pregnancy, vaccination of pregnant women at risk is not recommended.

Use in children

The use of the vaccine in children at risk from 2 years of age is shown.

special instructions

Vaccination is especially indicated for patients with sickle cell anemia, as well as those with asplenia who have undergone splenectomy or before splenectomy.

With revaccination carried out earlier than the due date, severe local reactions may occur.

In connection with the possibility of developing serious adverse reactions and complications (such as the Arthus phenomenon), contraindications should be strictly observed during vaccination, and the benefits of vaccination should be evaluated. At the same time, it should be taken into account that the determination of the effectiveness of pneumococcal vaccination was carried out only in individuals from risk groups.

Immunosuppressive therapy may reduce or completely suppress the immune response to the introduction of this vaccine.

drug interaction

Not marked.

Analogues of the drug Pneumo 23

Structural analogues for the active substance:

• Pneumovax 23 (Pneumococcal vaccine, polyvalent);
• Prevenar (pneumococcal polysaccharide conjugated adsorbed vaccine);
• Prevenar 13 (pneumococcal polysaccharide conjugated adsorbed vaccine, thirteen-valent);
• Synflorix (Vaccine 10-valent pneumococcal polysaccharide, conjugated with D-protein of non-typable Haemophilus influenzae, tetanus and diphtheria toxoids, adsorbed).

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Inpromed Medical Center participates in the action "Together against meningitis". The action is held in the city of Moscow. In the network of medical centers Inpromed, you can get vaccinated against meningitis with the Menactra vaccine (USA). Call and sign up!

PNEUMO-23 (vaccination against pneumonia)

Pneumo-23- vaccine against 23 pathogens of pneumonia (France).

Indications Pneumo 23

Prevention of infections of pneumococcal etiology (in particular pneumonia), in persons older than 2 years.

Vaccination is especially indicated for people from risk groups: over 65 years of age (primarily those who are constantly in special institutions for the care of the elderly); weakened or often hospitalized (patients with diabetes, chronic bronchitis, respiratory and heart failure); persons with alcohol or tobacco addiction; people with a weakened immune system (having undergone splenectomy, suffering from sickle cell anemia, having nephrotic syndrome); persons with leakage of cerebrospinal fluid.

Children's Medical Surveillance Programs

Take care of your baby! Choose a medical supervision program for your child!

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Everything must happen on time: observation, treatment, vaccinations, tests, massage... The child constantly requires attention, and sometimes mom and dad just can’t keep track of all the activities and procedures that the baby needs. Each age and each child needs an individual approach and an individual medical plan. That's why we've created Children's Surveillance Programs for children of all ages. Parents will be calm, and children will be healthy! Choose a medical supervision program for your child and don't worry about anything else!

Pneumococcal infection is a scourge of children's health. Pneumococci are microorganisms that cause pneumococcal infection, which adversely affects the child's body. This microbe is the main cause of diseases such as meningitis, sepsis and other terrible and unpleasant diseases that affect the heart, middle ear, bone marrow and soft tissues. Pneumo 23 according to Komarovsky's reviews - vaccination against different types of pneumococci.

Should children be vaccinated against pneumococcal disease? Each disease and inflammation in a child is stressful for a growing organism, as well as a vaccine. Dr. Komarovsky claims that pneumococcus causes the most dangerous diseases and complications in the body. These are pneumonia, accompanied by severe symptoms, and otitis, sinusitis, which disturb children with high regularity.
Vaccine opponents argue that pneumococcal infection can be cured without vaccinations, using only antibiotics. But do not forget that cases of severe infections caused by pneumococcus, and difficult to treat, have increased dramatically.

Komarovsky notes that these diseases are serious and only non-professionals can deny the usefulness of early vaccination against pneumococcus. However, most SARS are caused by viruses and pneumococcus has nothing to do with it. Therefore, the pneumococcal vaccine will not help in this situation.

When should one not vaccinate against pneumococcal infection according to Komarovsky?

At high temperatures, it is strictly forbidden to vaccinate a child! In this case, the likelihood of complications increases several times. In addition, if an allergic reaction to a previous vaccination occurs, it is prohibited to re-administer the drug.

According to Dr. Komarovsky, six-year-old children no longer need to be vaccinated against pneumococcus, since immunity is already similar to an adult and he can cope with the disease himself.

Vaccination Pneumo 23: the opinion of Dr. Komarovsky

Pneumo 23 is a safe vaccine. It has an advantage over most other vaccines. It consists of purified pneumococci, which contribute to the emergence of immunity against 23 bacterial serotypes. But its unique feature requires strict control of contraindications to the vaccine.

Contraindications

• SARS or a cold, expressed by high fever;
• Individual intolerance to the drug or one of its components;
• Chronic diseases in the acute phase;
• Allergic reaction to the first vaccination against pneumococcus.

At the same time, Komarovsky draws attention to the fact that each of the listed contraindications requires postponing the vaccination of Pneumo 23 for a while so as not to expose the child to the risk of contracting pneumococcal disease against the background of a weakened immune system. In case of allergy, subsequent vaccinations should be cancelled.
Before inoculating Pneumo 23, the doctor examines the child for allergies to the previous vaccine and measures the child's temperature. After that, it is decided whether the vaccine can be given now, it is worth postponing it for a more suitable time, or the vaccine should be canceled for good.

How to prepare a child for vaccination?

1. See a pediatrician before getting vaccinated.
2. Follow a hypoallergenic diet 3 days before vaccination. If the child is allergic, it is necessary to carry out therapy with antihistamine (antiallergic) drugs, the doctor prescribes the dose of the drug.
3. It is worth visiting the clinic in advance and taking blood and urine tests - this will allow the doctor to make sure that there are no inflammatory processes in the child's body. Remember, the tests are valid for 10 days, but to exclude the possibility of inflammatory processes in the body, it is worth taking the tests as close as possible to the immediate date of the decision of the vaccine.
4. DO NOT overfeed your child on the day of vaccination.
5. If someone in the family is sick or there is a suspicion that the child could be sick, postpone vaccination.
6. The vaccine must be of high quality and administered in accordance with the requirements.

Child's reaction to the Pneumo 23 vaccine

The Pneumo 23 vaccine incorporates purified pneumococcus - these are weakened microorganisms that do not cause disease in a healthy person, which contributes to the development of immunity against this microorganism. A natural thing will be a reaction to the introduction of an infectious agent. By mistake, some parents believe that the child is sick and the vaccine is to blame.

On the day the vaccine is administered, the child may experience redness of the injection site, fever, chills, mood changes, sleep and wakefulness disturbances. All this is a normal reaction of the body to the introduction of pneumococcus. Even safe, purified pneumococcus is still a pathological agent that enters from the outside. Thus, the listed symptoms mean the normal functioning of the immune system, therefore, the child's body fights the infection and develops immunity against it.

All that a child needs at the moment is the presence of parents nearby, their love and attention. Play with your child, distract him. The reaction to the Pneumo 23 vaccination passes in about a day.

Komarovsky notes that parents can provide proper care for the injection site. The adoption of water procedures during the production of Pneumo 23 is not prohibited, but the treatment of the injection site with antiseptics, ointments and the establishment of compresses, as well as gluing the injection site with a plaster is not recommended. The child's parents should monitor the baby's body temperature, if it rises above 38, then the child should be given an antipyretic without fail. The normal temperature when vaccinated against pneumococcal infection is 37.0-37.5. If the condition worsens, you should immediately seek help from the hospital.

Side effects of Pneumo 23 vaccination

1. swelling;
2. Weakness, soreness;
3. Redness of the injection site;
4. Increase in body temperature;
5. Pain in muscles and joints;
6. Skin rashes;
7. Anaphylactic reactions.

Interaction with other drugs

Interaction with other drugs has not been established. Therefore, this vaccine can be safely given to children who take drugs on an ongoing basis.
If there is a need to administer several vaccines on the same day, then they are administered with different syringes to separate parts of the body. The only vaccine that Pneumo 23 cannot be combined with is BCG (tuberculosis vaccine). In this case, it is better to postpone the vaccination of Pneumo 23 for 2 months.

Before you vaccinate, you must consult with a specialist about the need for a decision to vaccinate individually for each child.