Ambrobene for inhalation instructions for use. Ambrobene solution. The instructions for the drug indicate standard dosages.

Cough treatment requires certain knowledge. To date, pharmacological companies present a variety of drugs that can eliminate a cough of any origin.

In this regard, the selection of a drug is started only after a clear diagnosis has been established.

In our article, we will talk about a mucolytic and expectorant that has repeatedly proven its effectiveness in inflammatory processes in the lower part of the respiratory system - this is ambrobene. Let's get acquainted with the instructions for the drug, and determine which analogues can be used if ambrobene is not suitable for a particular patient.

The composition of the drug includes ambroxol, Its action is aimed at the production of special enzymes that prevent thickening of sputum, and also activate the production of surfactant. The main task of ambrobene is to thin and remove sputum from the respiratory tract. If the patient has a dry cough and sputum is difficult to separate, you can safely use ambrobene.

It has been proven that ambroxol also exhibits antioxidant properties, releasing free radicals from the respiratory tract.

Ambrobene is taken in the form of syrup, capsules, tablets, used for inhalation, and also administered intramuscularly. The concentration of the drug depends on the method of its administration, naturally, with the injection method, it is higher in the body. The presence of ambroxol during therapy is observed in breast milk and cerebrospinal fluid. The largest amount of the drug is concentrated in the lung tissue.

Ambrobene acts quite quickly, about 30-40 minutes after use. The duration of the therapeutic effect lasts up to 10 hours.

The average price for a drug in Russian pharmacies is as follows:

• solution for oral administration and inhalation 7.5 mg / ml 40 ml - 130 rubles;
• capsules 75mg No. 20 - 220 rubles;
• solution for injection 15mg / 2ml No. 5 - 200 rubles;
• syrup 15mg / 5ml 100ml - 120 rubles;
• tablets 100 mg No. 20 - 150 rubles.

Indications

Ambrobene for inhalation is suitable in the presence of a cough with viscous and difficult to separate sputum. This condition can be observed with bronchitis (any form), bronchiectasis, bronchial asthma, pneumonia. If a dry cough is a consequence of pharyngitis, ambrobene should not be used, because. the inflammatory process is in the pharynx.

Contraindications

The drug is well tolerated by patients, only in rare cases there is intolerance to the composition. The first and second period of pregnancy (up to about 28 weeks) is a contraindication for use.

Relative contraindications

There are pathologies in which ambrobene should be used with caution, they are as follows:

• renal and liver failure;
• immobile cilia syndrome, in which the motor function of the bronchi is impaired;
• ulcerative processes of the gastrointestinal tract.

All these contraindications are more related to the non-inhalation form of using ambrobene, when the medicine is intended for oral administration (goes directly into the stomach) or is administered as an injection. Therefore, inhalation is considered the safest way to administer the drug.

Adverse reactions

During inhalation, negative reactions are rare, but they are possible, these can be:

• cough;
• violation of taste;
• perspiration;
• dryness in the throat;
• hives;
• nausea;
• vomiting reflex;
• anaphylactic shock.

A stool disorder is possible only if the solution for inhalation enters the stomach, so the inhalation procedure must be carried out strictly according to the instructions.

Ambrobene for inhalation - dosages

Inhalations are often alternated or combined with internal administration of ambrobene. Therefore, consider the rules for taking the medicine in both cases.

Internal reception

The drug is always taken after a meal, it can be added to the liquid (tea, juice, compote).

1. For children under two years of age, a daily dose of 15 mg is recommended, i.e. morning and evening, 1 ml of ambrobene.
2. In the age category from two to six years, a daily intake is added, in the morning, afternoon and evening the child receives 1 ml of medication.
3. After six years, the daily dose increases to 30-45 mg. For adults, the maximum dose is allowed up to 90-120 mg per day.

Instructions for inhalation

Despite the simplicity of the inhalation method, it is still necessary to know certain dosage rules: how to observe rational proportions and dilute the drug, whether it is necessary to use bronchodilators before inhalation, and other nuances.

The most effective method of introducing ambrobene through the respiratory tract is considered to be inhalation using a nebulizer, when the solution is filled into the container of this device. Therapeutic vapors reach the desired area and are not sprayed on the sides. Steam inhalers are not suitable for this procedure.

Before filling the container, ambrobene is usually diluted in a 1: 1 ratio with saline (buy at a pharmacy). The dosage with saline may be different (check with your doctor).

The temperature of the treatment solution should be within 37 degrees. During inhalation, it is not necessary to take deep breaths, the patient breathes as usual. Sharp and drawn-out breaths provoke a cough, and interfere with an adequate procedure.

If the patient has bronchial asthma or COB (chronic obstructive bronchitis), it is recommended to use a bronchodilator in the form of a spray 20 minutes before inhalation.

Doses of ambrobene are taken into account according to the age category (in 1 ml - 7.5 mg of ambroxol):

• babies under two years old - 15 mg per day (the dose can be divided into two inhalations, i.e. 1 ml in the morning and one in the evening);
• from 2 to 6 years - the dose is doubled 2 ml in the morning and 2 ml in the evening;
• after 6 years, it is allowed to use 3 ml of solution per inhalation (up to 45 mg of the drug per day).

The duration of therapy and the frequency of inhalations is determined only by the doctor, depending on the patient's current history and concomitant chronic pathologies. Self-admission is possible for only five days.

To enhance the therapeutic effect during the use of all forms of ambrobene, it is recommended to consume more liquid, but this also requires the advice of a doctor, because. in some diseases, additional water intake can provoke, for example, an increase in blood pressure.

Sometimes parents ask the question: “How many drops of ambrobene do you need for inhalation?”. The question is not quite correct, for inhalation doses are calculated in milliliters. If the child does not want to breathe with the device and perform inhalations, most likely the pediatrician will suggest another form of ambrobene, for example, syrup, to treat cough.

Ambrobene analogues are cheaper

Ambrobene has many analogues, and if necessary, you can use the following drugs:

To carry out inhalation, you need the form of a solution, therefore, when purchasing an analogue for the inhalation procedure, do not forget about it.

Ambrobene is considered an inexpensive drug, and cheaper analogues are not so easy to find. For example, ambroxol in a solution of 100 ml costs 180 rubles, and ambrobene in the same form of 40 ml costs 130 rubles. It is clear here, it is more profitable to buy ambroxol. When purchasing an analogue, it is necessary to look not only at the price indicated on the box, but also at the concentration of the drug, as well as the quantity.

Doctors often offer a choice of several drugs, allowing the patient to decide for himself what is best. Naturally, in this case we are talking only about the price, because. not all patients have the opportunity to buy expensive drugs. Based on price, action and other criteria, let's compare lazolvan, ambrobene and acc.

Lazolvan or ambrobene?

Both drugs enhance the cough reflex, thin thickened sputum and remove it beyond the tracheobronchial tree. The effect of these two drugs is the same, because. they have one active substance - ambroxol, therefore, they are structural analogues.

Pharmaceutical companies that produce lazolvan and ambrobene are different. Lazolvan is a product of Italy or Greece, Ambrobene is produced in Germany and Austria. The therapeutic effect of the drugs is the same, although some patients "pull the blanket over themselves" in the direction of one of the drugs. Usually this is due to the financial ability to purchase medicines.

For ease of use, companies are trying to produce drugs in different dosage forms so that the doctor can choose the right and most effective for a particular patient. Ambrobene has more dosage forms than lazolvan. Compared with lazolvan, ambrobene has more contraindications. Rather, this is due to the composition of the excipients.

During the period of gestation and lactation, both drugs are not used. Also, drugs are not prescribed for a wet cough. Ambrobene has the advantage in price.

Which is better - ACC or Ambrobene?

In principle, both drugs have two goals - to thin and remove thickened sputum from the respiratory tract. In order to find other differences, it is necessary to study these drugs in more detail and determine what features there are.

If the question is “what is better to choose?”, we ask the doctor. The doctor has more experience in using such drugs, so he will tell you what is more effective in your case.

1. These drugs are not structural taxes, they have completely different main and auxiliary composition.
2. Acc and ambrobene are produced by different manufacturers. The first drug is a product of Germany, the second - of Germany and Austria. Manufacturers are different. There are significant differences in the form of release.
3. ACC has effervescent tablets, ambrobene is the usual tablet form. Ambrobene does not have capsules, but Azz does. Ambrobene and ACC both have a form for intramuscular and intravenous administration, as well as solutions and syrups used inside.

If you delve into the pharmacological action of these drugs, you will notice that they “work” in different ways. Ambrobene affects serous cells, protects the alveoli. Shows antiviral, antibacterial, anti-inflammatory, antioxidant activity.

ACC is able to destroy the chemical interaction between polysaccharides that maintain sputum in a viscous state. ACC also relieves inflammation, adversely affects the bacterial flora, has a detoxifying and antioxidant effect.

It can be concluded that the main difference between these drugs is their way of dealing with sputum. For many patients, this fact will seem insignificant, the main thing is that it helps. Hence, there are so many useless purchases, and disappointments when the drug does not “work” at all, which is why a doctor's consultation is always necessary.

Ambrobene or ace - often such a question is asked by mothers to pediatricians. First of all, you need to read the instructions for each remedy in detail, and make sure that your baby has no contraindications to their use. But remember, self-appointment is unacceptable.

Both drugs are not prescribed for children with intolerance to milk sugar and glucose-galactose malabsorption. Also, ambrobene and acc are not used in pediatrics with intolerance to the composition of any of them.

ACC and Ambrobene are prohibited in the first gestation period (up to 12-13 weeks). Capsules are allowed only after 12 years, tablets after 6 years, and inhalations are performed when the child can independently perform them.

Azz and ambrobene are allowed to be used up to the age of two (only with the permission of a pediatrician).

In any case, the best drug will be the one that suits each patient individually. The advantage of these funds is that they can be used from early childhood, when the child caught a virus, accompanied by a complication from the lower respiratory system. ACC and Ambrobene will be effective in the treatment of dry cough with sputum difficult to separate.

Compatibility of ACC and Ambrobene?

There are cases when ACC and Ambrobene are combined. Is it possible to do this, is it not harmful? The fact is that the drugs are similar in therapeutic effect, but have a different composition. Therefore, joint administration is permissible, but not immediately (at one time), but by alternating drugs.

This is done in the presence of addiction to one of the means, or when the inflammatory process has gained momentum. To achieve the effect of therapy, it is better, for example, to do the following. For inhalation, we use ACC, and we use lazolvan in syrup or tablets. Different ways of administering these drugs will only enhance the therapeutic effect.

Ambrobene is a mucolytic drug that has a positive effect on the drainage of pathological secretions. It improves the process of expectoration and has a positive effect on the rate of sputum excretion with a strong cough, and is used as an antiseptic.

Release form and composition

Ambrobene is a solution without much odor. Its color is quite pleasant - light yellow. Produced in vials with a darkened surface. The volume of the jar is 100 and 40 ml.

For inhalation, an inhaler is used, which allows you to quickly deliver the medicine to its destination.

The solution contains:

• ambroxol - 7.5 mg / ml;
• potassium sorbate - 1 mg;
• hydrochloric acid - 0.6 mg;
• purified water - 991.9 mg.

Attention! Ambrobene is sold in a box containing a glass bottle with a solution and a measuring cup.

Pharmacokinetics

A positive therapeutic effect, observed already 30 minutes after inhalation, is achieved due to the presence of ambroxol in the preparation. It enhances the activity of the ciliated epithelium, which covers the mucous membranes of the trachea, bronchi and lungs.

On the surface of the cells there are constantly moving cilia. Under the influence of ambrobene, they begin to move even faster. The accelerated movement of the cilia contributes to the rapid removal of the resulting sputum. Since Ambroxol affects the formation of sputum mucopolysaccharides, enzymes that destroy intramolecular bonds, and enhances the activity of serous cells, the sputum itself becomes less thick.

The liquid formed under the influence of the inhalation is excreted faster and better, the processes involved in this by the body are also accelerated.

The drug taken orally is 99% absorbed by the body. Withdrawal begins after 12 hours. 90% of it comes out in the form of metabolites, 10% is excreted unchanged. In the process of removing a substance from the body, the kidneys are involved, therefore, if patients have kidney-related diseases, the intensity of excretion decreases.

Indications for use

Ambrobene is effectively used to treat respiratory diseases. He easily copes with the removal of sputum and the destruction of the bacteria that caused it in ARVI, acute respiratory infections, bronchitis, pneumonia. The drug is prescribed for both adults and children.

children

Safe use of Ambrobene is possible from an early age. So, children under 2 years old receive a solution under the supervision of a pediatrician, older kids under the supervision of their parents. The main indicator for use is a cough. The drug copes well with both dry and wet forms. Ambrobene inhalations are carried out with:

• bronchitis;
• pneumonia;
• bronchial asthma.

Important! It is allowed to give the drug to children even if sputum is not observed when coughing. Pathologically dangerous mucus is still formed in the bronchi, the child will expectorate it a little later, with the help of Ambroxol it is possible to speed up this process and bring recovery closer.

Adults

Ambrobene is indicated for such diseases as:

• acute and chronic bronchitis of an infectious nature;
• chronic pathology in the structure of the bronchi;
• bronchial asthma;
• chronic obstructive bronchitis;
• pneumonia;
• tracheitis;
• cystic fibrosis;

Before using the drug, you need to consider the presence of contraindications and the existing risk of side effects.

Contraindications

The main contraindications include:

• sensitivity to its individual components;
• pregnancy;
• epileptic seizures;
• allergy.

Take the medicine with caution if:

• there are diseases and pathologies affecting the bronchi;
• sputum is formed and excreted at an unusual rate;
• gastric and duodenal ulcers are at the stage of exacerbation;
• kidneys are not working well;
• have liver problems.

If a woman is breastfeeding, then the appointment of the drug in question is undesirable. It easily passes into breast milk, which is not desirable and not always safe.

Method of application and dosage for inhalation

Ambrobene can be diluted and taken orally or inhaled. If this method of treatment has never been practiced before, it is better to study the instructions or make an appointment with a therapist. The specialist will tell you everything about how to carry out the procedure, develop a regimen for admission.

children

The dose of Ambrobene is calculated based on the age of the child. The following dosing options are available:

• Infants and children up to 2 years. To prepare a solution for inhalation of a baby, take 1 ml of the drug and dilute it with saline in equal proportions. Inhalation is done 1.5 hours after meals twice a day for 3-6 minutes.
• Children from 2 to 6 years old. To prepare the solution, take 2 ml of the drug and 2 ml of saline. Inhalation is carried out twice a day. The doctor will tell you more about how many times to do inhalation.

Attention! Children over 6 years of age take Ambrobene at a dose calculated for an adult, in accordance with the instructions for use.

Adults

For the treatment of adults, Ambrobene is diluted in a ratio of 2-3 ml of the drug for the same amount, approximately 2-3 ml of saline. Inhalation is done for 7 minutes for 7 days in a row. At least 2-3 inhalations should be carried out per day.

How to breed?

There is nothing complicated in diluting ambrobene for a nebulizer and preparing a solution for inhalation. In the pharmacy, you need to purchase a few ml of saline and the necessary medicine. Diluted in a ratio of 1:1. First, saline is drawn into a syringe or pipette and only then Ambrobene. The solution is shaken.

The finished product is heated to room temperature. To do this, a medicine container (pipette) is substituted under an ordinary table lamp.

How to do inhalation

Not knowing how to use Ambrobene, it is better to consult a doctor, as mentioned above. The finished medicine is inhaled for 3-7 minutes. Inhalations should be deep, and the rate of breathing should be constant. For convenience, the medicine is poured into a flat saucer, brought to the nose. From above, the patient is covered with a scarf or blanket, so that his head, together with the saucer, is wrapped up, and nothing prevents him from breathing the medicine. Inhalations with ambrobene and saline are quite pleasant.

Side effects

There are few side effects from ambrobene for inhalation, the use of which is described above. Most often they are the result of an overdose and manifest themselves in the form of:

• nausea;
• pain in the stomach;
• diarrhea;
• vomiting;
• taste disturbances.

With the development of allergies, itching, a rash on the skin, angioedema occur, signs of urticaria and anaphylactic shock appear. The result of exceeding the permissible dose is a decrease in blood pressure and an increase in salivation. Children may show signs of Stevens-Johnson or Lyell syndromes. When using ambrobene in the form of inhalation, the dosage is extremely important.

Use during pregnancy and lactation

Pregnant women use the medicine only on the recommendation of a leading specialist and in a smaller proportion than usual. There is no reliable data on the effect it has on the body of a woman and a child, but extra caution does not hurt.

Since it is known that ambroxol is able to penetrate into breast milk, it is still undesirable to be treated with it while breastfeeding a baby. If Ambrobene is nevertheless prescribed, then only in a situation where the benefits of taking it are greater than the possible risk.

If the medicine is taken orally, then it must be diluted with juice, water or tea, and only then used for its intended purpose. This allows you to make the reception more enjoyable. The drug is not allowed to be used in conjunction with antitussive drugs and drugs that prevent the removal of sputum.

If the color of the skin changes, the use of Ambrobene is stopped and immediately seek medical help.

If the drug is used simultaneously with amoxicillin, erythromycin and other antibiotics of this group, their total amount in sputum increases. Combining treatment with alcohol is not recommended.

Analogues

Ambrobene has a lot of analogues, all of them are also sold in the form of a solution for inhalation and are successfully used to treat the diseases listed above. Ambrobene can be replaced:

• Ambrohexal;
• Lazolvan;
• Ambroxol;
• Berodual;
• Berotecom;
• Sodium chloride.

If the form of release of the drug is not significant, then similar active and excipients are present in drops, tablets and syrups. Before buying a particular drug, you need to read the instructions and annotation for its use. The effect may be slightly different.

Terms and conditions of storage

Under the influence of sunlight, the active substance is destroyed, there will be no inhalation effect from its intake. After opening the bottle, it should be used as soon as possible and kept in a dark place. The drug is stored at temperatures up to 25 degrees. Shelf life - 5 years. An expired medicine can provoke the negative phenomena listed above, therefore it is better to throw away even an unopened package and purchase a new one.

Ambrobene is an antitussive drug with mucolytic (promoting sputum thinning) action. It has a positive effect on the lungs in the prenatal period.

Pharmacological action of Ambrobene

The active substance of the drug Ambrobene is ambroxol hydrochloride - a chemical compound that has a pronounced effect on the glandular cells of the bronchi and alveoli of the lungs. Reduces the viscosity of sputum (mucolytic action) by stimulating its secretion with increased secretion of surfactant - a surfactant contained in the lungs and bronchi with normalization of serous and mucosal, that is, liquid and viscous components of sputum. It affects the mobility of the cilia of the ciliated epithelium lining the respiratory tract, accelerating the movement of sputum outward (secretory effect).

In the prenatal (antenatal) period, it has a stimulating effect on the development of the lungs, increasing the production and release of surfactant, while preventing its decay. This action is associated with the use of Ambrobene to prevent pulmonary insufficiency in children born prematurely.

Release form and analogues

The drug Ambrobene is available in the following dosage forms:

• Tablets - 30 mg of active ingredient each, in a package of 20 pcs.;
• Capsules containing 75 mg of ambroxol hydrochloride, 10 and 20 pcs. packaged;
• Solution for oral and inhalation Ambrobene, with an active substance content of 7.5 mg per 1 ml, in vials of 40 and 100 ml;
• Solution for injection, also containing 7.5 mg of ambroxol per 1 ml of the drug, in ampoules of 2 ml, in a package of 5 pcs.;
• Ambrobene syrup, with an active substance content of 5 mg per 1 ml, in 100 ml vials.

Analogues of Ambrobene with the same active ingredient in the composition are drugs: Lazolvan, Ambroxol, Ambrosan, Medovent, Ambrohexal, Ambrolan, Ambrosol, Deflegmin, Bronchorus, Bronchoxol, Mucobron, Neo-bronchol, Suprima-cof, Fervex for cough, Flavamed, Halixol.

Indications for use Ambrobene

In accordance with the instructions, Ambrobene is effective in diseases of the respiratory tract, accompanied by sputum with increased viscosity. These include:

• Acute bronchitis;
• Chronical bronchitis;
• Bronchial asthma;
• Chronic obstructive pulmonary disease;
• bronchiectasis.

Also, this drug is used in obstetric practice to stimulate the maturation of the lungs, if it is necessary to conduct an artificial birth ahead of time or there is a threat of independent premature birth in the period of 28-34 weeks of pregnancy. Such use of Ambrobene is an effective prevention of respiratory distress syndrome, which often develops in premature babies due to the unwillingness of the lungs to perform their functions.

Dosage and scheme of application of Ambrobene

According to the instructions, Ambrobene is shown in the following dosages:

Adults and children over 12 years old: 1 tablet 3 times a day for the first 3 days, then 1 tablet 2 times a day, or ½ tablet 3 times a day until the cough subsides;

Ambrobene capsules take 1 capsule 1 time per day.

Parenteral: injection of 1 ampoule 2-3 times a day for adults, in severe condition, doubling the dosage is possible. For children, the dose for parenteral administration is calculated as 1.2-1.6 mg of ambroxol hydrochloride per 1 kg of body weight.

A solution for oral administration and inhalation Ambrobene is taken according to the scheme:

Adults, as well as children over 12 years old, 4 ml 3 r. per day for the first 3 days, then 4 ml 2 p. per day, or 2 ml 3 r. per day;

Up to 2 years, 1 ml 2 r. per day;

2-5 years 1 ml 3 r. per day;

5-12 years 2 ml 2-3 r. per day.

Ambrobene for inhalation is used as follows:

Adults, as well as children over 5 years old, 1-2 inhalations per day, 2 (children) -3 (adults) ml of solution;

Children under 5 years old - 1 inhalation per day, 2 ml of solution.

Syrup Ambrobene:

Adults and children over 12 years old 10 ml 3 times a day for the first 3 days of illness, then 10 ml 2 times a day or 5 ml 3 times a day;

up to 2 years, 2.5 ml 2 p. per day;

2-5 years 2.5 ml 3 r. per day;

5-12 years old, 5 ml of Ambrobene syrup 2-3 r. per day.

Treatment of pulmonary insufficiency in the prenatal period is carried out according to the scheme: 10 mg of ambroxol hydrochloride per 1 kg of body weight per day, divided into 3-4 parenteral injections. The maximum allowable dosage in case of a serious condition of the child is 30 mg of ambroxol hydrochloride per 1 kg of body weight per day, it must also be divided into 3-4 injections.

Contraindications to the use of Ambrobene

The use of Ambrobene is contraindicated in the following situations:

• Individual intolerance to ambroxol hydrochloride;
• Ulcerative diseases of the gastrointestinal tract;
• 1 trimester of pregnancy;
• breastfeeding period.

Unwanted Effects

When the dosage is observed in accordance with the instructions, Ambrobene, as a rule, is well tolerated, its administration rarely leads to side effects. However, in clinical practice, when using it, the following side effects were recorded:

• From the immune system: allergic reactions of delayed and immediate types (urticaria, exanthema, angioedema, anaphylactic shock);
• On the part of the respiratory tract - shortness of breath, a feeling of dryness in the respiratory tract, rhinorrhea;
• From the urinary organs - dysuria;
• From the nervous system - headache;
• On the part of the digestive tract - dyspeptic phenomena of varying intensity (nausea, vomiting, diarrhea, pain in the epigastric region);
• From the side of the cardiovascular system - lowering blood pressure;
• Miscellaneous - fever, chills, dry mouth.

special instructions

Ambrobene may interact with other medicinal substances, which should be taken into account in complex therapy. Pharmacologically incompatible with drugs that have an alkaline reaction, their combined use is unacceptable due to possible neutralization (Ambrobene solution has an acidic reaction).

Do not use simultaneously with other antitussive drugs due to a decrease in the therapeutic effect.

The effect of the use of Ambrobene is enhanced against the background of heavy drinking, therefore, during therapy with this drug, it is necessary to observe a drinking regimen with a high fluid content.

Conditions and terms of storage of Ambrobene

Store in a sealed package out of direct sunlight, in a place inaccessible to children with an air temperature not exceeding 25 ° C.

Under these conditions, the shelf life of all forms of the drug is 5 years.

It is possible to leave Ambrobene without a doctor's prescription.

Ambrobene for inhalation, the instructions for use of which are written available, is a clear liquid that has a yellow or brown tint.

The solution for inhalation procedures is odorless. This drug belongs to the mucolytic group of drugs. In addition, it has expectorant properties. The manufacturing company also produces Ambrobene - tablets (instructions for use are attached). The solution contains not only Ambroxol, but also additional substances: hydrochloric acid, potassium sorbate and water. The substance is produced in special vials-containers. Their volume is 40 and 100 ml. The packages contain droppers in the form of corks and special glasses for measuring volumes. Solutions can be taken orally, and also used for inhalation procedures.

Indications for the use of the drug

Indications for the use of ambrobene (solution for inhalation) are diseases of the respiratory system. In particular, the drug is prescribed in cases where the respiratory tract of the human body is affected. This medicine is used in cases where there are problems with sputum and mucus production and its discharge.

Pharmacological effect

Ambrobene refers to drugs that have a mucolytic and expectorant effect. The composition of the drug includes a substance such as Ambroxol. It is a type of bromhexine. If you take the drug orally, the effect of its action will come no later than half an hour. The effect of the drug can last from 6 to 12 hours, depending on what dosage was used.

Studies of the action of the drug have shown that it affects the cells of the glands that are responsible for the mucous membranes. Cells that belong to the ciliated type of epithelium begin to activate, which reduces the viscosity of mucus and sputum. After that, the transportation of sputum for its removal from the body improves.

How the drug interacts with other drugs

If you take Ambroxol with drugs that fight cough, side effects may occur. This is due to the fact that the cough reflex will be suppressed. This will cause the secret to stagnate. In this regard, combinations of medicines must be selected very carefully. Only a doctor can prescribe all medicines.

If you combine Ambroxol with drugs that belong to the group of antibiotics, then the concentration of antibiotic substances in mucus and sputum will increase. These antibiotics include amoxiclav, erythromycin, cefuroxime, and doxycycline.

Dosage when taking the drug inside

When ambrobene is used for inhalation, the instruction of which does not require a doctor's decoding, then the correct dosage must be observed so that side effects from the use of the drug do not appear. The course of treatment is prescribed by a doctor. It sets the duration of the drug. The duration of this period depends on the individual characteristics of the patient's body, the severity of his disease and other factors. Without consulting a doctor, it is forbidden to use the drug for more than 5 days. The mucolytic effect of ambrobene for inhalation (the price is acceptable and may vary slightly) will only appear if the patient drinks a lot of liquids.

The solution should be used only after meals. For oral administration, the solution must be mixed with other liquids. Water, juice, iced tea, etc. will do.

If it is necessary to take the solution inside, then children under 2 years of age are allowed a dosage of up to 1 ml 2 times a day. This dose is 15 mg ambroxol per day. 1 ml of solution contains 7.5 mg of ambroxol. For children from 2 to 6 years old, it is allowed to take 1 ml of liquid three times a day. Between the ages of 6 and 12 years, the dosage is 2 ml. You need to take the remedy 2 or 3 times a day.

If a teenager or an adult is sick, then the dosage is 4 ml. The procedure should be carried out 3 times a day. This scheme is provided for the first 3 days. Then you need to take the drug 4 ml, but only 2 times a day.

Ambrobene for inhalation procedures: dosage

Ambrobene for inhalation, reviews of which are positive, must be applied using a special inhaler or nebulizer. You can use any design, but there is an exception - it is forbidden to use steam options. Before carrying out inhalations with ambrobene and saline, you should consult with your doctor regarding the period of use of the drug, the duration of the procedures and the amount of liquid used.

First, ambrobene must be diluted with sodium chloride. It is best to mix the substance in equal proportions. The solution should be 0.9%. Then the liquid must be heated to the required temperature. The procedure must be carried out very carefully so as not to cause a cough in the patient.

Patients who suffer from asthma of the bronchial type should start inhalation procedures only after taking drugs that belong to bronchodilator groups. Children who have not yet reached 2 years of age are allowed to carry out inhalation procedures, but only up to 1 ml of solution can be used. Moreover, the procedure can be carried out no more than 2 times a day. If the child is from 2 to 6 years old, then the dose is increased to 2 ml. The inhalation procedure can be carried out twice a day. If the child is over 6 years old, then the dosage for inhalation procedures is increased to 3 ml.

Overdose

Ambrobene tablets and solutions should be taken very carefully. Otherwise, the thoughtless use of the medication can lead to an overdose. Signs of this phenomenon are the usual symptoms of intoxication of the human body. In general, there are no serious consequences from taking the drug, but patients may experience nervous excitement. In some cases, diarrhea occurs. If you take only 25 mg per day for every kilogram of human weight, then Ambroxol will be easily tolerated by the patient's body. If you greatly increase the dosage, then the person may increase salivation. There are nausea and vomiting attacks. In some cases, blood pressure may decrease.

To eliminate such symptoms of poisoning, it is necessary to use standard methods of intensive care. These include the induction of vomiting attacks and the use of means for washing the digestive tract. However, it is allowed to start such methods of treating a patient from an overdose only if severe signs of poisoning appear, and the drug was taken no later than 2 hours ago. After that, the doctor prescribes symptomatic treatment for the patient.

Contraindications to the use of the drug

Ambrobene for inhalation is an effective remedy, but in some cases it is forbidden to use this drug. For example, this tool is not recommended for people who have individual intolerance to the components of the drug. Also, this remedy is prohibited for women during pregnancy in the first trimester.

Very carefully you need to treat this medication to people who have problems with the bronchi, when their motor functionality is impaired. The same applies to people who have excessive sputum production. Also, it is necessary to be careful with the drug for those patients who have ulcerative pathologies of the gastrointestinal tract, especially during the period of exacerbation of these diseases. The same applies to women in the second and third trimester of pregnancy, as well as during breastfeeding. Children under 2 years of age can use the drug only if the doctor has allowed.

If there are liver and kidney diseases in severe form, then it is necessary to observe long time periods between doses of the drug. Moreover, the dosage should be very small. It is allowed to use this medicine only with the permission of the attending physician.

This drug should not be combined with medicines that belong to the antitussive group, because. they prevent the release of mucus from the human body.

If any side effects appear, then you should consult a doctor for additional diagnostics. In very rare cases, the patient may have a negative reaction to Ambroxol, which will be expressed in violations of the integrity of the skin.

If there are side effects that prevent a person from performing various actions related to caution and concentration, then it is necessary to abandon the drug for driving a car and other vehicles. Very rarely, the speed of mental and motor reactions can decrease. It is best to stay at home during treatment and not bother yourself with additional tasks - the patient should be at rest more to lie down.

Side effects

In some cases, there are side effects from the use of the drug. They can affect the nervous system, code and mucous membranes, the immune system, the digestive tract, or cause standard allergic reactions of the human body to irritants. These side effects occur in less than 1 percent of all patients.

For example, the patient may have problems with the gastrointestinal tract. Sometimes the mucous membrane of the throat, nose and oral cavity is strongly dried. In rare cases, nausea and bouts of vomiting occur. Very rarely, the stomach can start to hurt. In more severe situations, diarrhea and dyspepsia appear.

As for problems with the nervous system, only a small percentage of all patients develop a problem with taste sensitivity.

As for the immune response of the body to the use of the drug, in rare cases hypersensitivity appears.

From the allergic group of symptoms in patients with individual intolerance to the ingredients of the drug, urticaria may appear. Sometimes a rash, burning, swelling and itching appear on the skin. In rare cases, taking the drug can lead to anaphylactic shock.

Ambrobene is a solution for inhalation, the instructions for which are simple, used for children and adults. This substance perfectly copes with various diseases and helps to remove phlegm from the respiratory tract. By the way, there are also ambrobene tablets (the instruction is similar to using a solution). Before using this drug, you should consult your doctor. It is best not to use the drug with other medicines that have antitussive properties. Ambroxol is a safe remedy that has practically no side effects, but you must definitely follow the rules for using the drug and read the dosage.

Ambrobene: instructions for use and reviews

Latin name: Ambrobene

ATX code: R05CB06

Active substance: Ambroxol hydrochloride (Ambroxol hydrochloride)

Manufacturer: Ratiopharm GmbH, Merckle (Germany), Teva (Israel)

Description and photo update: 13.08.2019

Ambrobene is a mucolytic agent that has a secretolytic, secretomotor and expectorant effect.

Release form and composition

Ambrobene is produced in the following forms:

• Capsules;
• Pills;
• Injection;
• Solution for inhalation and oral administration;
• Syrup.

As part of all forms of the drug, the active ingredient is ambroxol hydrochloride.

Ambrobene capsules contain the following excipients:

• Methylhydroxypropylcellulose;
• MCC and sodium carboxymethylcellulose;
• Colloidal silicon precipitated;
• Triethyl citrate;
• Iron oxide (black, yellow, red);
• Gelatin;
• titanium dioxide.

Capsules are issued in blisters. In one blister - 10 pieces. The package contains 1 or 2 blisters.

Auxiliary components in Ambrobene tablets are highly dispersed silicon dioxide, corn starch, lactose and magnesium stearate. In one carton box 2 blisters of 10 tablets.

Ambrobene injection solution contains as excipients:

• Disodium monohydrogen phosphate heptahydrate;
• Citric acid monohydrate;
• Water for injection;
• Sodium chloride.

Ambrobene solution for injection is available in ampoules of 2 ml in a blister pack. One package contains 5 pieces.

Ambrobene solution for inhalation and oral administration, in addition to the active substance, contains purified water, potassium sorbate and hydrochloric acid. It is sold in dark glass dropper bottles of 40 or 100 ml. They come with a measuring cup.

Ambrobene syrup contains liquid sorbitol, raspberry flavor, purified water, propylene glycol and saccharin. It is sold in dark glass bottles of 100 ml. They also come with a measuring cup.

Pharmacological properties

Pharmacodynamics

Ambroxol belongs to the group of benzylamines and is a metabolite of bromhexine. It differs from the latter by the presence of a hydroxyl group located in the para-trans position of the cyclohexyl ring and the absence of a methyl group. The active component of Ambrobene is characterized by expectorant, secretolytic and secretomotor action.

Preclinical studies prove that Ambroxol stimulates the serous cells of glands located on the bronchial mucosa. By activating the cells of the ciliated epithelium and reducing the viscosity of sputum, it improves mucociliary transport.

Ambroxol provides a more intense production of surfactant by directly acting on type 2 alveolar pneumocytes and Clara cells located in the small airways.

In vivo studies in animals and experiments on cell cultures indicate that ambroxol activates the synthesis and secretion of surfactant, which is active on the surface of the bronchi and alveoli in both the adult and the embryo. Preclinical studies have also confirmed the antioxidant effect of ambroxol. When Ambrobene is taken together with some antibiotics (doxycycline, amoxicillin, erythromycin and cefuroxime), their content in sputum and bronchial secretions increases.

Pharmacokinetics

When administered parenterally, Ambroxol penetrates the tissues quickly enough, when taken orally, it is completely absorbed from the gastrointestinal tract. The maximum concentration of this substance is found in the lungs and is reached 1-3 hours after administration / ingestion. The substance binds to plasma proteins by approximately 80-90% (mean 85%). The plasma half-life is 7-12 hours. The total half-life of ambroxol and its metabolites is approximately 22 hours.

Less than 10% of ambroxol is excreted unchanged through the kidneys, 90% of the administered dose is excreted as metabolites in the same way. Since ambroxol is highly protein bound, has a large volume of distribution, and is slowly redistributed from tissues to the blood, dialysis or forced diuresis does not significantly affect its excretion.

In patients with severe liver dysfunctions, ambroxol clearance is reduced by 20-40%. The substance crosses the placental barrier and into the cerebrospinal fluid, and is also excreted in breast milk.

Indications for use

According to the instructions, Ambrobene is prescribed for the following diseases:

• Pneumonia;
• Chronic and acute bronchitis;
• bronchiectasis;
• Chronic obstructive pulmonary disease, including bronchial asthma with difficult sputum discharge;

Ambrobene can also be used as part of complex therapy for respiratory distress syndrome in newborns and premature babies to stimulate the synthesis of surfactant.

Contraindications

• Hypersensitivity;
• epileptic syndrome;
• Peptic ulcer of the stomach and duodenum;
• The period of breastfeeding;
• First trimester of pregnancy.

With caution, Ambrobene is prescribed for:

• severe liver disease;
• Impaired kidney function;
• Large volumes of allocated secret;
• Bronchial motility disorder.

Instructions for use Ambrobene: method and dosage

The method of application of Ambrobene depends on the form of release:

• Capsules (1 capsule - 75 mg ambroxol hydrochloride). In this form, Ambrobene is indicated for children over 12 years of age and adults at a dose corresponding to 1 capsule per day;
• Tablets (1 tablet - 30 mg ambroxol hydrochloride). For adults, the scheme of application is as follows: 1 tablet 3 times a day (the first 2-3 days), then the frequency of doses is reduced to 2 times a day, or a single dose is reduced to 1/2 tablet while maintaining 3 doses;
• Ambrobene injection solution (1 ampoule - 15 mg ambroxol hydrochloride). Adults with a multiplicity of 2-3 doses are usually prescribed 1 ampoule, however, in severe cases, an increase in a single dose is possible. The daily dose for children is calculated according to the following scheme: 1.2-1.6 mg of ambroxol chloride is multiplied by the weight of the child in kg. The instructions for Ambrobene indicate the following doses: 1/2 ampoules for children under 2 years old (2 times a day) and children from 2 to 5 years old (3 times a day), and children 5-12 years old are prescribed 1 ampoule, with a frequency of use 2-3 times a day. In the treatment of choking syndrome in newborns and premature infants, Ambrobene is prescribed in 3-4 doses, and the daily dose is calculated by multiplying 10 mg of ambroxol hydrochloride by the child's weight in kg. In severe cases, with caution, the daily dose can be increased by 3 times;
• Ambrobene solution for inhalation and oral administration (1 ml contains 7.5 mg of ambroxol hydrochloride). The first 2-3 days for adults, the drug is prescribed 4 ml, with the frequency of doses - 3 times, then the frequency is reduced to 2 times while maintaining a single dose, or the dose is reduced to 2 ml, but taken 3 times a day. For children under 2 years of age, a single dose of 1 ml should be given 2 times a day; increase the number of doses up to 3 times while maintaining a single dose is necessary for children 2-5 years old; 2-3 times a day, a single dose (2 ml) is prescribed for children 5-12 years old;
• Ambrobene syrup (5 ml - 15 mg of ambroxol hydrochloride). For ease of use, a measuring glass is attached to the preparation, one division on which corresponds to 1 ml of syrup. For adults, a single dose is 10 ml, which are taken in 3 doses for the first 2-3 days, followed by a decrease to 2 times. Also, after 2-3 days of treatment, it is possible to reduce the dose to 5 ml while maintaining a three-time intake. For children under 2 years old, the drug is prescribed in a volume of 2.5 ml 2 times in laziness, for children 2-5 years old, the same dose is prescribed 3 times a day, for children 5-12 years old, syrup should be given 5 ml 2 or 3 times a day.

After using Ambrobene inside, the drug begins to act in half an hour, the effect persists for 6-12 hours.

Ambrobene is excreted in breast milk, penetrates the blood-brain and placental barriers.

Side effects

According to the instructions, Ambrobene can cause the following undesirable reactions of the body:

• Hives;
• Skin rash;
• Angioedema;
• Extremely rare - allergic contact dermatitis, anaphylactic shock;
• Diarrhea;
• Constipation;
• dry mouth;
• Rhinorrhea;
• Headache.

Prolonged use of Ambrobene can cause nausea, vomiting, gastralgia. Rapid administration of the drug can cause weakness, a feeling of numbness, lowering blood pressure, intense headache, hyperthermia, shortness of breath and chills.

In case of an overdose, diarrhea, vomiting, dyspepsia are possible, which are eliminated by gastric lavage or inducing vomiting, and the intake of fat-containing foods can also help.

Overdose

With an overdose of Ambrobene, the symptoms of intoxication practically do not appear. In some cases, increased nervous excitement and diarrhea have been reported. When taken orally in a daily dose not exceeding 25 mg/kg, ambroxol is well tolerated. When using Ambrobene in very high doses, a decrease in blood pressure, nausea, vomiting, and increased salivation are sometimes observed.

In the event of an extremely severe overdose, intensive care methods, including induction of vomiting, are used as treatment. Gastric lavage is most effective only in the first 1-2 hours after taking the drug. Symptomatic therapy is also prescribed.

special instructions

In rare cases, the use of Ambrobene can cause severe skin reactions (Lyell's syndrome and Stevens-Johnson syndrome). If changes in the mucous membranes or skin occur after taking the drug, stop taking the drug and immediately consult a doctor.

Influence on the ability to drive vehicles and complex mechanisms

The effect of ambroxol on the ability to drive vehicles and work with moving mechanisms is currently not well understood.

Use during pregnancy and lactation

Information regarding the use of Ambroxol during the first 28 weeks of pregnancy is currently insufficient to determine the safety and efficacy of treatment with the drug in this category of patients. The appointment of the drug in the II and III trimesters of pregnancy is possible only after consultation with a specialist and determining the ratio of the potential benefits of therapy for the mother and the likely risks to the fetus.

The use of Ambrobene during lactation has not been sufficiently studied, therefore, only a doctor should prescribe it after a thorough assessment of the ratio of the possible benefits of treatment for the mother and the potential risks for the infant.

Experimental studies conducted on animals do not indicate the presence of a teratogenic effect, but prove that ambroxol is excreted in breast milk.

Application in childhood

Ambrobene in the form of a solution for injection and tablets should not be used in children under 6 years of age. Capsules are contraindicated for use in children under 12 years of age.

Treatment of children under 2 years of age should be carried out exclusively under the supervision of a physician.

For impaired renal function

For impaired liver function

The drug should be used with caution in patients with severe liver dysfunction, reducing the dose and increasing the time interval between doses of Ambrobene. The course of treatment is carried out only under the supervision of a doctor.

drug interaction

When ambroxol is combined with antitussives, due to inhibition of the cough reflex, secretion stagnation may develop. For this reason, such combinations must be chosen with care.

The combined use of Ambrobene and antibiotics (doxycycline, amoxicillin, erythromycin and cefuroxime) leads to an increase in the concentration of the latter in bronchial secretions and sputum.

Analogues

Analogues of Ambrobene are the following drugs: Ambrolan; Bronchoxol; Ambrosan; Deflegmin; Bronchorus; Remebrox; Halixol; Flavamed.

Terms and conditions of storage

Ambrobene must be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C.

The shelf life of the drug is 4 years.