Artrosilene is a drug from a number of NSAIDs. The main medicinal substance of this drug is the lysine salt of ketoprofen. This substance is much better tolerated by patients than diclofenac-containing tablets, since it does not have a negative effect on the mucous membrane of the gastrointestinal tract.
For the convenience of treatment, Artrosilene is produced in various forms:
- Artrosilene gel for superficial use;
- capsules;
- suppositories for rectal use;
- injection solutions;
- Artrosilene spray for dermal use.
Drug Effects
Each of the pharmacological forms of Artrozilene has anti-inflammatory, analgesic and antipyretic effects. The use of this tool provides an increase in the motor ability of the diseased joint, reduces the manifestation of joint stiffness in the morning, and eliminates swelling in the area of inflammation.
Lysine salt dissolves quickly, due to which it does not have an aggressive effect on the gastrointestinal tract. External use of the drug allows you to enhance the effect of the drug locally at the site of the lesion. The effect is enhanced by the complex use of several forms of Artrosilene.
When is the drug prescribed?
This remedy in the form of suppositories or capsules is recommended for such conditions:
- moderate joint pain associated with surgery, trauma or inflammation;
- arthritis of gouty or rheumatoid origin;
- osteoarthritis;
- the spread of the inflammatory process to the soft tissues adjacent to the joints;
- spondyloarthritis.
Injectable forms of Artrozilene are prescribed for severe pain syndrome for a short course of therapy for such pathologies:
- pathology of the musculoskeletal system in the acute phase of inflammation;
- post-traumatic or postoperative pain syndrome.
Forms for external use are prescribed for chronic pain of low intensity or as an addition to the main treatment for the following conditions:
- injuries of soft tissue structures;
- muscle pain of various etiologies;
- diseases of the osteoarticular system, accompanied by inflammatory and destructive processes in the joints.
It should be noted that contraindications to the appointment of this drug may differ slightly, depending on the pharmacological form of release. Consider the conditions in which it is not recommended to use this medicine in any form:
- pregnancy and breastfeeding;
- Crohn's disease or non-specific ulcerative colitis;
- diverticulitis;
- asthma "aspirin";
- severe renal failure;
- individual intolerance to the components of the drug;
- peptic ulcer or peptic ulcer;
- hemophilia and other blood pathologies.
- eczema;
- weeping type dermatosis;
- skin damage.
The use of Artrozilene in patients with such diagnoses requires special care:
- liver failure;
- chronic heart failure;
- anemia;
- alcoholism;
- bronchial asthma;
- diabetes.
Side effects of the drug on the body
Side effects from the use of Artrozilene, given the feedback from patients, may be different. However, they all manifest themselves based on the individual characteristics of the organism. Most often, according to the reviews of patients, undesirable effects on the background of the use of the drug appear in the form of functional disorders:
- sense organs;
- heart and blood vessels;
- nervous system;
- respiratory organs;
- liver;
- urinary organs;
- hematopoietic organs.
When using forms for external use, allergic rashes, photosensitivity or other skin reactions are possible. If any side effect is detected, a specialist consultation and treatment correction is required.
How to use Artrosilene?
Instructions for use of the drug is attached to each package of the drug, regardless of the form of release. It is possible to use Artrozilene in several ways: inside, rectally, externally and by injection.
Capsules are prescribed 1 piece per day after meals. Treatment involving the use of this medicine in the form of capsules can last about 3-4 months. Given the feedback from patients, capsules are the most convenient form of taking the drug. However, the use of capsules in the treatment of chronic pathologies of the musculoskeletal system is accompanied by uncontrolled drug intake. Although cases of drug overdose have not been recorded, it should be remembered that indefinitely long-term use of capsules can provoke serious complications.
The injection form of Artrozilene is intended for intravenous or intramuscular injection into the patient's body. The frequency of admission is also once a day. Injections are chosen for a short course of treatment lasting up to 3 days. If further treatment is necessary, it is recommended to switch to capsules or suppositories.
Suppositories can be used up to 2-3 times a day. For elderly patients, the use of Artrozilene in this form is not recommended more than 2 times a day.
Forms for surface use are usually applied up to 3 times a day. The dosage of an aerosol for single use is 1-2 g. The duration of such treatment should be no more than ten days.
Application features
- When using suppositories, capsules or injections in treatment regimens, you should periodically monitor the indicators of a general blood test, as well as renal function and liver performance (biochemical studies).
- Treatment with this agent can reduce the severity of the clinical manifestations of an infectious disease.
- With reduced liver and kidney function, it is recommended to reduce the dose of the drug.
- The drug can significantly reduce the ability of the egg to implant, therefore, before planning a pregnancy, the course of treatment should be interrupted.
- If it is necessary to determine the level of 17-ketosteroids in the body, you should stop taking the drug at least two days before the analysis.
- It is possible to apply external forms of Artrozilene only on undamaged skin.
- This tool enhances the effect of substances and drugs such as: heparin, vitamin K antagonists, antithrombotic agents, ethanol alcohol, drugs with lithium, glucocorticoids, methotrexate, hypoglycemic drugs.
Artrozilena's analogs
The analogues of the drug include the following means:
- Quickcaps;
- Ketonal Duo;
- Arquetal;
- Bystrumgel;
- Ketoprofen;
- Fastum;
- Rompharm;
- Febrofid;
- Flamax.
Despite the abundance of analogues, nevertheless, you should not choose a replacement for Artrozan on your own. Do not rely on positive reviews about the drug on the Internet or the approval of a pharmacist. To select an analogue, it is better to consult a doctor.
Artrosilene: instructions for use and reviews
Latin name: artrosilene
ATX code: M02AA10
Active substance: ketoprofen (ketoprofen)
Producer: Dompe Farmaceutici (Italy), ISTITUTO de ANGELI (Italy), Zellaerosol GmbH (Germany), Valpharma S.A. (San Marino), Alfa Wassermann (Italy), Abiogen Pharma S.p.A. (Italy)
Description and photo update: 09.09.2019
Artrosilene is a drug with analgesic, antipyretic and anti-inflammatory action.
Release form and composition
Dosage forms of Artrozilene release:
- capsules: gelatinous, oblong, white body and dark green cap, the capsules contain round granules from light yellow to white (10 pieces in blisters, 1 blister in a cardboard box);
- solution for intravenous / intramuscular administration: transparent, slightly yellowish or colorless (in dark glass ampoules of 2 ml, 6 ampoules in a pallet, 1 pallet in a cardboard box);
- rectal suppositories: from light yellow to white, homogeneous, torpedo-shaped (5 pcs in strips, 2 strips in a cardboard box);
- gel for external use: transparent, light yellow, has a characteristic odor (30 or 50 g in aluminum tubes, 1 tube in a cardboard box);
- aerosol for external use: homogeneous, almost white or white foam, which is formed when released from the container; the contents of the container after the release of the gas is a transparent liquid from light yellow to white (25 g in aluminum aerosol cans with a capacity of 25 ml, 1 container in a cardboard box complete with a protective cap and spray nozzle).
Each pack also contains instructions for the use of Artrozilene.
Composition of 1 capsule:
- active substance: lysine salt of ketoprofen - 320 mg;
- auxiliary components: povidone -27.857 mg; diethyl phthalate - 2.286 mg; polymers of methacrylic and acrylic acids -34.143 mg; carboxypolymethylene - 32.857 mg; talc -27 mg; magnesium stearate -15.857 mg;
- capsule shell: titanium dioxide (E171), gelatin; cap (optional) - indigotine (E132), quinoline yellow (E104).
Composition of 1 ml solution for injection:
- active ingredient: lysine salt of ketoprofen - 80 mg;
- auxiliary components: citric acid, sodium hydroxide, water for injection.
Composition of 1 suppository:
- active ingredient: lysine salt of ketoprofen - 160 mg;
- auxiliary component: semi-synthetic glycerides.
Composition of 100 mg gel:
- active substance: lysine ketoprofen (lysine salt of ketoprofen) - 5 mg (ketoprofen - 3.125 mg);
- auxiliary components: carbomer - 1 mg; trolamine - 1.9 mg; polysorbate-80 - 0.8 mg; 95% ethanol - 5 mg; methyl parahydroxybenzoate - 0.1 mg; lavender-neroli flavoring - 0.2 mg; purified water - 0.086 ml.
Composition of 100 mg aerosol:
- active ingredient: lysine ketoprofen (lysine salt of ketoprofen) - 15 mg (ketoprofen - 9.375 mg);
- auxiliary components: propylene glycol - 4 mg; polysorbate-80 - 4 mg; lavender-neroli flavoring - 0.2 mg; povidone - 3 mg; propane-butane mixture - 1.25 mg; benzyl alcohol - 0.3 mg; purified water - up to 0.1 ml.
Pharmacological properties
Pharmacodynamics
Ketoprofen has anti-inflammatory, antipyretic and analgesic effects. Inhibits the synthesis of prostaglandins, inhibiting COX (cyclooxygenase) I and II types. It exhibits anti-bradykinin activity, stabilizes lysosomal membranes and delays the release of enzymes from them, which contribute to tissue destruction in chronic inflammation. Inhibits the activity of neutrophils, reduces the release of cytokines.
Thanks to the use of ketoprofen, morning stiffness and swelling of the joints are reduced, and the range of motion is increased. Unlike ketoprofen, ketoprofen lysine salt is a fast-dissolving molecule with a neutral pH and almost no irritant effect on the gastrointestinal tract.
When using an aerosol or gel Artrosilene, a local therapeutic effect is provided in relation to the affected ligaments, muscles, joints, tendons. Ketoprofen has no catabolic effect on articular cartilage.
Pharmacokinetics
Capsules, rectal suppositories, injection solution
Suction:
- capsules: ketoprofen after oral administration is almost completely absorbed from the gastrointestinal tract, its bioavailability is more than 80%. C max (maximum concentration of a substance) in plasma is reached in 4-10 hours, its value is dose-dependent and is 3-9 μg / ml. T 1/2 (half-life) - 6.5 hours. The maximum therapeutic effect is observed within 4-24 hours. Food reduces C max and lengthens the time to reach it, while AUC (the area under the concentration-time curve) does not change;
- rectal suppositories: ketoprofen is rapidly absorbed after rectal administration. The time to reach Cmax is from 45 to 60 minutes. The value of plasma concentration linearly depends on the accepted dose.
- injection solution: when administered parenterally, the time to reach C max is 20-30 minutes. The effective concentration is maintained for 24 hours. In the synovial fluid, the therapeutic concentration lasts from 18 to 20 hours;
Up to 99% of the absorbed ketoprofen binds to plasma proteins, mainly albumin. V d (volume of distribution) is in the range from 0.1 to 0.2 l/kg. It penetrates easily through histohematic barriers, is distributed in organs and tissues. The substance penetrates well into connective tissues and synovial fluid. Although the concentration of ketoprofen in the synovial fluid is slightly lower than the plasma concentration, it is more stable (lasts up to 30 hours).
The metabolism of ketoprofen occurs mainly in the liver, where the substance undergoes glucuronidation, followed by the formation of esters with glucuronic acid.
Excretion of metabolites is carried out with urine. With feces, up to 1% is excreted. Does not accumulate.
With external use, ketoprofen is absorbed slowly.
A dose of 50-150 mg of gel after 5-8 hours creates a plasma level of 0.08-0.15 µg / ml. The bioavailability of the gel is approximately 5%.
The level of ketoprofen in the blood after applying the aerosol is less than 0.1 μg / ml, the amount of the substance (free or conjugated) excreted in the next 48 hours by the kidneys is equivalent to 0.62% of the dose of the drug. The level of ketoprofen in the synovial fluid is equivalent to 0.2–2 μg / ml (depending on the applied dose).
Indications for use
Capsules, rectal suppositories
- pain of mild / moderate intensity, including inflammatory pain, postoperative / post-traumatic pain (stopping);
- rheumatic / inflammatory diseases, including spondyloarthritis, osteoarthritis, rheumatoid / gouty arthritis, inflammatory lesions of the periarticular tissues (symptomatic treatment).
injection solution
Acute pain syndrome in the presence of the following diseases / conditions (short treatment):
- diseases of the musculoskeletal system of various etiologies;
- postoperative / post-traumatic period;
- inflammatory processes.
Gel, aerosol for external use
- muscle pain of non-rheumatic / rheumatic origin;
- inflammatory diseases of the musculoskeletal system in acute and chronic course, including ankylosing spondylitis, rheumatoid / psoriatic arthritis, osteoarthritis of the spine and peripheral joints, rheumatic lesions of soft tissues;
- injuries of soft tissues of traumatic origin.
Contraindications
Absolute contraindications for Artrozilene in all dosage forms:
- "aspirin triad";
- pregnancy (III trimester) and lactation;
- hypersensitivity to the components of Artrosilene, as well as to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.
Additional absolute contraindications for systemic use:
- blood clotting disorders, including hemophilia;
- peptic ulcer of the stomach and duodenum during exacerbation;
- ulcerative colitis during exacerbation;
- diverticulitis;
- Crohn's disease;
- peptic ulcer;
- chronic renal failure;
- age up to 18 years.
Additional absolute contraindications for external use:
- violation of the integrity of the skin;
- eczema;
- weeping dermatoses;
- age up to 6 years.
Relative (the appointment of Artrozilene in all dosage forms requires caution in the presence of the following diseases / conditions):
- I and II trimesters of pregnancy;
- elderly age.
Relative contraindications for the systemic use of Artrozilene:
- smoking;
- anemia;
- alcoholism;
- sepsis;
- bronchial asthma;
- diabetes;
- arterial hypertension;
- swelling;
- hyperbilirubinemia;
- alcoholic cirrhosis of the liver;
- liver failure;
- dehydration;
- deficiency of glucose-6-phosphate dehydrogenase;
- stomatitis;
- blood disorders, including leukopenia.
Relative contraindications for external use of Artrozilene:
- erosive and ulcerative lesions of the gastrointestinal tract;
- bronchial asthma;
- chronic heart failure;
- hepatic porphyria during exacerbation;
- severe functional disorders of the kidneys / liver;
- age from 6 to 12 years.
Artrosilene, instructions for use: method and dosage
Capsules
Artrosilene capsules are taken orally, preferably at the same time / after a meal.
Daily dose - 1 capsule (in 1 dose).
It is possible to conduct a long course - from 3 to 4 months.
Rectal suppositories
Artrosilene is used rectally.
Single dose - 1 suppository, frequency of use - 2-3 times a day.
The maximum daily dose is 3 suppositories, for elderly patients - no more than 2 suppositories per day.
With functional disorders of the liver / kidneys, a dose reduction is required.
injection solution
Artrosilene injections are administered intramuscularly or intravenously.
The daily dose is 160 mg.
Maximum - 320 mg per day, elderly patients - 160 mg per day.
In the form of injections, Artrosilene is used for a short time (up to 3 days), after which they switch to the use of capsules or suppositories.
Intravenous solution is administered only in stationary conditions. To increase the duration of action of Artrozilene, slow intravenous infusions are recommended - at least 30 minutes.
The solution for infusion is prepared on the basis of 50 or 500 ml of the following aqueous solutions: 0.9% sodium chloride solution, 10% aqueous solution of levulose, 5% aqueous solution of dextrose, Ringer's acetate solution, Hartmann's Ringer's lactate solution, colloidal solution of dextran in 5% dextrose solution or 0.9% sodium chloride solution.
When diluting Artrozilene in small volumes (50 ml) of the solution, it is administered intravenously as a bolus.
Gel, aerosol for external use
Gel and spray Artrosilene is used externally.
The drug is applied 2-3 times a day, rubbing it gently until completely absorbed.
Duration of the course - up to 10 days (unless otherwise prescribed by the doctor).
Side effects
- central and peripheral nervous system: general malaise, hyperkinesia, dizziness, tremor, vertigo, anxiety, mood swings, irritability, hallucinations, visual impairment;
- digestive system: duodenitis, abdominal pain, gastritis, diarrhea, esophagitis, stomatitis, erosive and ulcerative lesions of the gastrointestinal tract, melena, hematemesis, increased bilirubin levels, liver failure, hepatitis, increased activity of liver enzymes, enlarged liver;
- urinary system: painful urination, edema, cystitis, hematuria;
- cardiovascular system: syncope, hypertension, tachycardia, hypotension, chest pain, pallor, peripheral edema;
- hematopoietic system: thrombocytopenia, leukocytopenia, lymphangitis, thrombocytopenic purpura, leukocytosis, decreased prothrombin time, vasculitis, enlarged spleen;
- respiratory system: laryngeal edema, sensation of laryngeal spasm, bronchospasm, dyspnea, laryngospasm, rhinitis;
- allergic and dermatological reactions: angioedema, urticaria, erythema multiforme exudative (including Stevens-Johnson syndrome), maculopapular rash, anaphylactoid reactions (swelling of the pharynx, oral mucosa, periorbital edema), itching, erythematous exanthema;
- others: menstrual disorders, conjunctivitis, increased sweating;
- local reactions with external use: photosensitivity, skin manifestations of allergic reactions; with prolonged use on large areas of the skin - the development of systemic side effects;
- local reactions when using suppositories: exacerbation of hemorrhoids, itching, burning, heaviness in the anorectal region.
In comparison with ketoprofen, the lysine salt of ketoprofen causes side reactions much less frequently.
Overdose
Cases of an overdose of Artrozilene with systemic use have not been registered. With external use, an overdose is practically impossible, due to the extremely low systemic absorption of ketoprofen.
Therapy: monitoring of cardiac and respiratory activity. If necessary, symptomatic treatment is carried out. There is no specific antidote. Hemodialysis is ineffective.
special instructions
During the period of therapy, periodic monitoring of the picture of peripheral blood and the functional state of the kidneys / liver is required.
If it is necessary to determine 17-ketosteroids, Artrozilene is canceled 2 days before the study.
Therapy may mask the symptoms of an infectious disease.
In bronchial asthma, the use of Artrozilene can lead to the development of an asthma attack.
Externally, the drug can only be applied to intact areas of the skin. Avoid getting Artrosilene in the eyes and mucous membranes.
Aqueous solutions of the lysine salt of ketoprofen, as well as an external gel, can be used in physiotherapy (mesotherapy, iontophoresis): during iontophoresis, the drug is applied to the negative pole.
In order to prevent manifestations of photo- and hypersensitivity, it is recommended to avoid exposure to the skin of sunlight during the treatment course.
Influence on the ability to drive vehicles and complex mechanisms
During the use of Artrozilene, potentially dangerous types of work, the implementation of which requires increased concentration of attention and quick psychomotor reactions, should be refrained from.
Use during pregnancy and lactation
- III trimester of pregnancy, breastfeeding period: therapy is contraindicated;
- I and II trimesters of pregnancy: Artrozilen can be used only under medical supervision.
Application in childhood
Age restrictions on the use of Artrozilene:
- gel, aerosol: children under 6 years of age are contraindicated; children 6-12 years old - are prescribed with caution;
- capsules, injection solution, rectal suppositories: children under 18 are contraindicated.
For impaired renal function
Artrosilene in the form of capsules, solution and suppositories in chronic renal failure is contraindicated.
Aerosol and gel Artrosilene in severe renal impairment should be used with caution.
For impaired liver function
The use of Artrozilene requires caution:
- capsules, solution and suppositories: for patients with alcoholic cirrhosis of the liver and liver failure;
- gel, aerosol: for severe hepatic impairment.
Use in the elderly
Elderly patients Artrozilene is prescribed with caution.
drug interaction
With the combined use of Artrozilene with certain drugs / substances, the following effects may develop:
- inducers of microsomal oxidation in the liver, including ethanol, tricyclic antidepressants, phenytoin, phenylbutazone, barbiturates, rifampicin, flumecinol: increased metabolism of ketoprofen (there is an increase in the production of hydroxylated active metabolites);
- anticoagulants, antiplatelet agents, fibrinolytics, ethanol: enhancing their action;
- uricosuric, antihypertensive drugs, diuretics: a decrease in their effectiveness;
- other non-steroidal anti-inflammatory drugs, glucocorticosteroids, ethanol, corticotropin: an increase in the likelihood of ulceration and the occurrence of gastrointestinal bleeding, functional disorders of the kidneys;
- mineralocorticoids, glucocorticoids, estrogens: increased severity of their side effects;
- insulin and oral hypoglycemic drugs: increased hypoglycemic effect (dose adjustment may be required);
- oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefamandol and cefotetan: increased likelihood of bleeding;
- verapamil, nifedipine, lithium, methotrexate: increase in their plasma concentration;
- sodium valproate: violation of platelet aggregation;
- cholestyramine, antacids: decreased absorption of ketoprofen.
Analogues
Artrozilen's analogues are: Febrofid, Ketoprofen, Fastum, Oruvel, Spazgel, Ketospray, Flexen, VALUSAL, Artrum, Ketonal, Bystrumgel.
Terms and conditions of storage
Store in a place protected from light, out of the reach of children, at temperatures up to 25 °C. The aerosol can must not be overheated.
Best before date:
- capsules, rectal suppositories - 5 years;
- solution for injection, gel, aerosol - 3 years.
Terms of dispensing from pharmacies
Released:
- capsules, solution, suppositories: by prescription;
- gel, aerosol: no prescription.
Unfortunately, no one is immune from injury. Some injuries are so severe that it is impossible to do without the help of a specialist. The doctor will not only help to avoid the inflammatory process, but also save the patient from unbearable pain. In case of serious injuries and after surgical interventions, the drug "Artrosilene" is often used. Injections are prescribed in the most difficult cases. In pharmacies, you can find medicine in the form of a solution, suppositories and tablets.
The composition of the drug
The drug belongs to the category Ketoprofen lysine salt acts as the main active ingredient. Additionally, substances such as sodium hydroxide, citric acid, and purified water are used. The drug is supplied to pharmacies in glass ampoules packed in cardboard boxes.
It has a complex effect means "Artrosilen". Injections help relieve fever, remove inflammation, and also produce an analgesic effect. The patient feels relief already in the first days of therapy. Ketoprofen lysine salt is an instant compound. Due to this, during the treatment process, the patient practically does not irritate the gastrointestinal tract. The main active ingredient does not affect articular cartilage either. During the treatment, the patient does not feel morning stiffness and swelling of the joints.
Pharmacokinetics
During oral administration, the capsules of the drug are quickly absorbed from the gastrointestinal tract. The maximum bioavailability can be 80% and is achieved after 4-5 hours. Bioavailability indicators directly depend on the dose that the patient takes. Experts do not recommend taking the medicine with food. This contributes to a significant decrease in the bioavailability of the main active ingredient.
When administered intravenously or intramuscularly, the drug is also rapidly absorbed. The maximum plasma concentration can be reached after 40 minutes. The therapeutic effect is maintained throughout the day. More than 95% of the main active ingredient binds to plasma proteins. Ketoprofen lysine salt easily penetrates through the walls of blood vessels and is distributed in tissues and organs. Due to this, the analgesic effect is achieved fairly quickly.
Indications
The instructions for use attached to the preparation "Artrozilene" must first be studied by those who were injured. Injections may not be for everyone. The drug belongs to the category of potent and can be used for fairly serious injuries or as a prophylactic medicine after surgical interventions.
Short-term treatment of pain syndrome is acceptable for diseases of the musculoskeletal system. At the same time, they are prescribed only as part of the complex therapy "Artrosilen" (injections). Reviews show that the drug partially eliminates inflammation, and also relieves pain. To eliminate the cause of the disease, it is necessary to use special medications of a narrow profile.
Do not use the drug "Artrosilene" without consulting a doctor. Injections also have their contraindications. In addition, experts do not recommend a potent remedy for minor injuries.
Contraindications
Should be studied before using the drug "Artrozilene" instructions for use. Injections are not for everyone. So, a potent drug is not prescribed to minors. Cannot be used by women during pregnancy and lactation. There are also a number of serious contraindications related to the patient's state of health. If a person is diagnosed with peptic ulcer of the stomach and duodenum, bleeding disorders, diverticulitis or chronic renal failure, it is better to choose another medication.
As practice shows, in most cases it is in the hospital that the treatment with the drug "Artrosilen" is carried out. Injections can be prescribed only after a complete examination of a sick person and a diagnosis. A qualified specialist should initially study the patient's medical history in order to exclude the possible development of side effects and other negative reactions, not forgetting the existing contraindications. The drug is prescribed with caution to patients suffering from diabetes mellitus, liver failure, chronic heart failure.
special instructions
Before starting treatment, the specialist is obliged to check the picture of peripheral blood, as well as the functional state of the liver and kidneys. It should be borne in mind that taking Artrosilen can mask the presence of an infectious disease. This is due to the fact that the medicine removes the pain syndrome, the patient's well-being improves significantly. At the same time, the drug has no effect on the development of infection.
As the reviews show, at the beginning of therapy, Artrosilene causes rather unpleasant sensations. The injections are painful, and therefore patients are quite difficult to tolerate the procedure, although there are exceptions. Medicine knows cases of loss of consciousness during manipulations. Experts recommend giving injections in a supine position. More unpleasant are However, the pain passes quite quickly.
Dosage
At the initial stage, the drug is prescribed intravenously or intramuscularly at 160 mg per day (1 ampoule). In the most difficult cases, the daily rate can be doubled. The maximum daily dose should not exceed two ampoules. Patients over 65 years of age are not prescribed more than 160 mg per day. The same rule applies to people with liver failure. How long should I take "Artrosilene"? Injections are given no more than three days. Further, experts recommend switching to the use of suppositories or tablets. Injections are made only in a hospital setting.
You can prolong the time of action of the drug with the help of infusions, when the drug is administered intravenously for half an hour. The drug can be prepared on the basis of a solution of sodium chloride, an aqueous solution of levulose, a solution of dextose.
The procedural sisters say that people tolerate the introduction of the drug "Artrosilene" in different ways. The injections are painful. As already mentioned, sometimes patients even for a short moment lost consciousness during the procedure. According to some patients, the pain syndrome is not so pronounced, although, of course, the sensations are rather unpleasant. If you take injections in a supine position, the procedure is tolerated a little easier.
Overdose
The dosage should be strictly observed using "Artrosilene" (injections). Reviews of experts show that improper use of the drug can lead to a deterioration in the patient's well-being. There are unpleasant symptoms from the gastrointestinal tract. The patient may feel nausea, stomach pain, dizziness.
In case of overdose, symptomatic therapy is carried out. The doctor must necessarily monitor the respiratory and cardiovascular systems.
Side effects
May provoke the development of side effects "Artrosilen" (injections). Analogues can also contribute to the appearance of unpleasant symptoms. Therefore, they should be used to treat a specific pathology only after consulting a doctor. On the part of the digestive system, side effects can manifest themselves in the form of abdominal pain, stomatitis, increased activity of liver enzymes, and erosive lesions of the gastrointestinal tract.
From the side of the central nervous system, dizziness, tremor of the extremities, vertigo, disturbances of nocturnal sleep were observed. In some cases, visual impairment occurs. It is worth remembering that the drug "Artrozilen" (injections) and alcohol are incompatible. Alcohol primarily contributes to the development of negative reactions. The most difficult are the side effects from the cardiovascular system. Patients may experience chest pain, tachycardia, syncope. Hypertension often develops.
drug interaction
Significantly increase the metabolism of ketoprofen inductors in the liver, such as phenytoin, ethanol, rifampicin, barbiturates. Against the background of taking the drug "Artrozilene", the effectiveness of uricosuric drugs may be reduced. It is not recommended to combine the drug with antihypertensive drugs, as well as diuretics.
With other non-steroidal anti-inflammatory drugs, it is necessary to carefully combine injections of "Artrosilene". The instruction states that such an interaction can lead to the development of gastric ulcer, as well as gastrointestinal bleeding. There is a high probability of impaired renal function.
The drug is prescribed with caution to people suffering from diabetes. With the simultaneous use of ketoprofen and insulin, the concentration of the latter in the blood may increase. Diabetics need to recalculate the dose before starting treatment.
Artrosilene gel is actively used in rheumatology, orthopedics and traumatology for the treatment of pathologies of the joints and spine. A drug from the group of non-steroidal anti-inflammatory drugs (NSAIDs) is prescribed to patients to eliminate pain, swelling, and hyperemia.
He quickly copes with all the symptoms of arthritis, osteoarthritis, osteochondrosis, spondylarthrosis and tendinitis. For patients with fractures and injuries of the ligamentous tendon apparatus, Artrozilene allows to speed up rehabilitation.
The high therapeutic efficacy of the gel is somewhat minimized by a wide list of contraindications. A violation of the dosing regimen can cause the development of local and systemic adverse reactions. Gel Artrosilene should be used only on prescription after a series of instrumental studies.
The active ingredient of Artrosilene is ketoprofen, a derivative of propionic acid. The chemical compound has pronounced anti-inflammatory, analgesic, analgesic properties.
Such a complex effect of the drug is widely used in the treatment of diseases of the musculoskeletal system. It is included in treatment regimens to eliminate morning swelling of the joints and stiffness of movements.
At the stage of exacerbation of any pathology, the use of the gel helps to get rid of sharp, piercing pains. And at the stage of remission, an external agent allows you to stop the uncomfortable sensations of a aching, pressing character.
What gel Artrosilene is used for in medicine:- treatment of joint diseases accompanied by an inflammatory process. All NSAIDs effectively cope with inflammation, but the remedy with ketoprofen is considered the least toxic. Artrosilen accelerates the resorption of edema, which provokes muscle spasm and compression of the nerve roots. Its use helps to alleviate symptoms, prevents the spread of pathology to healthy tissues;
- therapy of degenerative-dystrophic diseases. The slow destruction of cartilage tissue significantly reduces the functional activity of the joints. And the further formation of osteophytes (bone outgrowths) significantly worsens their condition. The use of the gel increases the range of motion, reduces the severity of pain, swelling of soft tissues.
The therapeutic line of Artrosilene includes injection solutions, gel, capsules, aerosol, rectal suppositories. When choosing a dosage form, the doctor takes into account the degree of its toxic effect on internal organs.
The gel penetrates into the bloodstream in a small amount, accumulating in pathological foci. Therefore, rheumatologists and orthopedists often prefer this particular remedy for external use.
Clinical and pharmacological group
Artrosilene is a representative of the clinical and pharmacological group of non-steroidal anti-inflammatory drugs for external use.
pharmachologic effect
The instructions for the Artrosilene gel give a detailed description of its therapeutic properties. They are based on the pharmacological action of its active ingredient ketoprofen. The chemical compound has the ability to inhibit cyclooxygenase, which stimulates the synthesis of prostaglandins.
As a result, their production from arachidonic acids slows down or completely stops. Ketoprofen suppresses the production of other mediators of fever, pain and inflammation - bradykinins and leukotrienes.
Other pharmacological properties are also characteristic of the drug:- stabilization of lysosome membranes;
- preventing the release of enzymes that destroy tissues;
- inhibition of the penetration of leukocytes and neutrophils into pathological foci.
After applying the product, swelling and stiffness of the joints are eliminated within an hour. The analgesic effect is achieved by stopping the inflammatory process and reducing the intensity of soft tissue edema. Improves blood circulation and production of synovial fluid, accelerates the regeneration of muscles, ligaments, tendons.
Release form and composition
The Italian manufacturer produces Artrosilene in aluminum tubes, each of which contains 30 or 50 g of 5% of the product. The secondary packaging is a cardboard box with instructions for use inside.
Artrosilene is a transparent gel of jelly-like consistency with a pleasant smell of orange and lavender. Its active ingredient is ketoprofen from the NSAID group. The auxiliary composition of the drug is represented by the following components:
- carboxypolymethylene;
- triethanolamine;
- polysorbate;
- ethyl alcohol;
- methyl p-hydroxybenzoate;
- purified water;
- flavors.
Artrosilene gel contains ingredients that prolong and enhance the anti-inflammatory effect of ketoprofen. They provide its transdermal and transepidermal absorption into the affected joints.
Terms and conditions of storage
The shelf life of the drug is 36 months, after opening the aluminum tube it is limited to 3-4 weeks. Artrosilene is intended for storage in places protected from sunlight. The optimum temperature regime is 15-25°C. In case of violation of storage conditions, the product exfoliates, changes color and smell. This indicates its deterioration and unsuitability for treatment.
Instructions for use
The instructions for the use of Artrozilene recommend using the gel as prescribed by the doctor. The drug is intended only for symptomatic therapy. Its active ingredient does not have a pathogenetic therapeutic effect on the human body.
Many articular inflammatory pathologies are of autoimmune or infectious origin. In such cases, it is necessary to use antibiotics, antiviral agents, drugs for the correction of immunity.
Indications and contraindications
Artrosilene is used to treat pathologies of the joints and the spinal column. It quickly relieves pain, inflammation, swelling. Therefore, it is prescribed to eliminate symptoms, both in acute and chronic diseases.
Indications for the use of an external agent are:- rheumatic, gouty, reactive, infectious arthritis;
- osteoarthritis of large and (or) small joints;
- tendinitis, tendovaginitis;
- epicondylitis lateral or medial;
- contractures of various localization;
- cervical, thoracic, lumbosacral osteochondrosis;
- spondyloarthritis.
The drug is included in therapeutic schemes at the stage of rehabilitation after injury to the joints, spine. It helps to accelerate the healing of tissues in case of fractures, dislocations, ruptures of muscles, ligaments, tendons.
Artrosilene is not used in case of hypersensitivity to the ingredients, during lactation, in late pregnancy. Contraindications also become ulcerative lesions of the gastrointestinal tract, gastritis, intolerance to NSAIDs. It is forbidden to use the gel for Crohn's disease, severe pathologies of the liver and kidneys, hematopoietic disorders.
Dosage and administration
Artrosilene gel (cream, ointment) is used 2-3 times a day. It is applied in a thin layer on areas of pain and inflammation, lightly rubbed until completely absorbed. Single and daily dosages are determined by the attending physician. It takes into account the stage of pathology, the degree of tissue damage, the size of the damaged joint.
For a long time, the drug is strictly forbidden to use. If after 10 days of treatment the pain persists, then it is necessary to inform the doctor about this. It will replace Artrozilene with an active analogue from the NSAID group.
Side effects and special instructions
In rare cases, after applying the gel, the development of local allergic reactions is noted. Clinically, they are manifested in swelling and redness of the skin, rashes, itching, and pain. You should stop using the drug and consult a doctor.
It is possible to combine Artrozilene with other means for the treatment of joints. It is combined with preparations containing capsaicin, dimethyl sulfoxide, salicylic acid and snake venom. It is not advisable to use the gel together with glucocorticosteroids and other NSAIDs.
Prices and terms of dispensing from pharmacies
5% gel - over-the-counter drug. The average cost of a gel pack in pharmacies is 160 rubles.
Analogues
Structural analogues of Artrozilene - gels Febrofid, Fastum,. Its substitutes are Voltaren, Indomethacin, Nise, Nimulide, Diclofenac, Diclak, Ortofen.
Osteoarthritis, rheumatoid arthritis and other diseases of the joints and spine, occurring with pain and inflammation.
Peculiarities: all drugs in this group act on a similar principle and cause three main effects: analgesic, anti-inflammatory and antipyretic.
In different drugs, these effects are expressed to varying degrees, so some drugs are better suited for the long-term treatment of joint diseases, others are mainly used as painkillers and antipyretics.
The most common side effects: allergic reactions, nausea, abdominal pain, erosion and ulcers of the mucous membrane of the gastrointestinal tract.
Main contraindications: individual intolerance, exacerbation of peptic ulcer of the stomach and duodenum.
Important information for the patient:
Drugs that have a pronounced analgesic effect and a significant number of side effects (diclofenac, ketorolac, nimesulide and others) can only be used as directed by a doctor.
Among non-steroidal anti-inflammatory drugs, a group of so-called "selective" drugs is distinguished, which are less likely to have side effects from the gastrointestinal tract.
Even over-the-counter pain relievers cannot be used long-term. If they are required frequently, several times a week, it is necessary to be examined by a doctor and treated according to the recommendations of a rheumatologist or neurologist.
In some cases, long-term use of this group of drugs requires additional intake of proton pump inhibitors that protect the stomach.
| Trade name of the drug | Price range (Russia, rub.) | Features of the drug, which is important for the patient to know |
| Active substance: diclofenac | ||
| Voltaren(Novartis) | A powerful pain reliever, mainly used for back and joint pain. It is undesirable to use for a long time, as the drug has numerous side effects. May adversely affect liver function, cause headache, dizziness and tinnitus. Contraindicated in "aspirin" asthma, disorders of hematopoiesis and blood coagulation processes. Do not use during pregnancy, breastfeeding and children under 6 years of age. | |
| diclofenac(various manufacturers) | ||
| Naklofen(Krka) | ||
| Ortofen(various manufacturers) | ||
| Rapten Rapid(Stada) | ||
| Active substance: Indomethacin | ||
| Indomethacin(various manufacturers) | 11,4-29,5 | It has a powerful anti-inflammatory and analgesic effect. However, it is considered quite outdated, as it leads in the likelihood of developing a variety of side effects. It has many contraindications, including the III trimester of pregnancy, the age of up to 14 years. |
| Metindol retard(Polfa) | 68-131,5 | |
| Active substance: diclofenac + paracetamol | ||
| Panoksen(Oxford Laboratories) | 59-69 | A powerful two-component pain reliever. It is used to reduce severe pain and inflammation in arthritis, osteoarthritis, osteochondrosis, lumbago, dental and other diseases. Side effects - like diclofenac. Contraindications are inflammatory bowel disease, severe hepatic, renal and heart failure, the period after coronary artery bypass grafting, progressive kidney disease, active liver disease, pregnancy, breastfeeding, childhood. |
| Active substance: Tenoxicam | ||
| Texamen(Mustafa Nevzat Ilach Sanai) | 186-355 | It has a powerful analgesic and anti-inflammatory effect, the antipyretic effect is less pronounced. A distinctive feature of the drug is a long duration of action: more than a day. Indications are radicular syndrome in osteochondrosis, osteoarthritis with inflammation in the joints, neuralgia, muscle pain. Has a number of side effects. Contraindicated in bleeding from the gastrointestinal tract, pregnancy and during breastfeeding. |
| Active substance: Ketoprofen | ||
| artrosilene(Dompe Pharmaceuticals) | 154-331 | A drug with a pronounced analgesic and anti-inflammatory effect. Does not adversely affect the condition of the articular cartilage. Indications for use are symptomatic therapy of various arthritis, osteoarthritis, gout, headache, neuralgia, sciatica, muscle pain, post-traumatic and postoperative pain, pain syndrome in oncological diseases, painful periods. It causes many side effects and has many contraindications, including the III trimester of pregnancy and breastfeeding. In children, age restrictions depend on the trade name of the drug. |
| Quickcaps(Medana pharma) | 161-274 | |
| Ketonal (Lek. d.d.) | 93-137 | |
| Ketonal duo(Lek. d. d.) | 211,9-295 | |
| Oki (Dompe Pharmaceuticals) | 170-319 | |
| Flamax(Sotex) | 86,7-165,8 | |
| Flamax forte(Sotex) | 105-156,28 | |
| Flexen(Italfarmaco) | 97-397 | |
| Active substance: Dexketoprofen | ||
| Dexalgin(Berlin-Chemie/Menarini) | 185-343 | New powerful drug of short-term action. The analgesic effect occurs 30 minutes after taking the drug and lasts from 4 to 6 hours. Indications for use are acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondyloarthritis, arthrosis, osteochondrosis), pain during menstruation, toothache. Side effects and contraindications are similar to those of other drugs. In general, with short-term use according to indications and at recommended doses, it is well tolerated. |
| Active substance: Ibuprofen | ||
| Ibuprofen(various manufacturers) | 5,5-15,9 | It is most often used as an antipyretic drug and a remedy for relieving headaches. However, in large doses it can also be used for diseases of the spine, joints and to relieve pain after bruises and other injuries. There may be side effects from the gastrointestinal tract, hematopoietic organs, as well as headache, dizziness, insomnia, increased blood pressure and a number of other undesirable reactions. It has many contraindications. Can not be used in the III trimester of pregnancy and while breastfeeding, in the I and II trimester it must be used with caution, only on the advice of a doctor. cha. |
| Burana (Orion Corporation) | 46,3-98 | |
| Ibufen (Polfa, Medana pharma) | 69-95,5 | |
| Moment (Berlin-Chemie/Menarini) | 71,6-99,83 | |
| Nurofen(Reckitt Benckiser) | 35,65-50 | |
| Nurofen Ultracap(Reckitt Benckiser) | 116-122,56 | |
| Nurofen Express(Reckitt Benckiser) | 102-124,4 | |
| Nurofen Express Neo(Reckitt Benckiser) | 65-84 | |
| Faspik(Zambon) | 80-115 | |
| Active substance: ibuprofen + paracetamol | ||
| Ibuklin(Dr. Reddy's) | 78-234,5 | Combined preparation containing two analgesic and antipyretic substances. It works more powerful than the same drugs taken separately. It can be used for pain in the joints and spine, injuries. However, it does not have a very pronounced anti-inflammatory effect, therefore, it is not recommended for long-term treatment in rheumatic diseases. It has many side effects and contraindications. Do not use in children under 12 years of age, as well as in the III trimester of pregnancy and while breastfeeding. |
| Brustan(Ranbaxi) | 60-121 | |
| Next(Pharmstandard) | 83-137 | |
| Active substance: Nimesulide | ||
| nise(Dr. Reddy's) | 111-225 | Selective analgesic drug, mainly used for back and joint pain. May also relieve period pain, headaches and toothaches. It has a selective effect, therefore it has less negative effect on the gastrointestinal tract. However, it has a number of contraindications and side effects. It is contraindicated during pregnancy and lactation; in children, age restrictions depend on the trade name of the drug. |
| Nimesulide(various manufacturers) | 65-79 | |
| Aponil(Medochemi) | 71-155,5 | |
| Nemulex(Sotex) | 125-512,17 | |
| Nimesil(Berlin-Chemie/Menarini) | 426,4-990 | |
| Nimika (IPKA) | 52,88-179,2 | |
| Nimulid(Panacea Biotek) | 195-332,5 | |
| Active substance: Naproxen | ||
| Nalgezin(Krka) | 104-255 | A powerful drug. It is used to treat arthritis, osteoarthritis, adnexitis, exacerbation of gout, neuralgia, sciatica, pain in the bones, tendons and muscles, headache and toothache, pain in cancer and after surgery. It has quite a few contraindications and can cause a variety of side effects, so long-term treatment is possible only under the supervision of a physician. |
| Naproxen(Pharmstandard) | 56,5-107 | |
| Naproxen-acry (Akrikhin) | 97,5-115,5 | |
| Active substance: Naproxen + esomeprazole | ||
| Vimovo(AstraZeneca) | 265-460 | Combination preparation containing naproxen with analgesic and anti-inflammatory action and proton pump inhibitor esomeprazole. Developed in the form of tablets with sequential delivery of substances: the shell contains immediate release esomeprazole magnesium, and the core contains sustained release enteric-coated naproxen. As a result, esomeprazole is released in the stomach before naproxen dissolves, which protects the gastric mucosa from the possible negative effects of naproxen. Indicated for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in patients at risk of gastric and duodenal ulcers. Despite good protective properties against the stomach, it can cause a number of other side effects. Contraindicated in severe liver, heart and kidney failure, gastrointestinal and other bleeding, cerebral hemorrhage and a number of other diseases and conditions. Not recommended in the III trimester of pregnancy, while breastfeeding and children under 18 years of age. |
| Active substance: Amtolmetin guacil | ||
| Nizilat(Dr. Reddy's) | 310-533 | A new non-steroidal anti-inflammatory drug with a minimal negative effect on the gastric mucosa. Despite a number of possible side effects, it was generally well tolerated by patients (including long-term use for 6 months). It can be used both for rheumatic diseases (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, etc.), and for the treatment of pain syndromes of other origin. It has a lot of contraindications. Not applicable during pregnancy, breastfeeding and under the age of 18 years. |
| Active substance: Ketorolac | ||
| Ketanov(Ranbaxi) | 214-286,19 | One of the most potent analgesics. Due to the large number of contraindications and side effects, it should be used occasionally and only in cases of very severe pain. |
| Ketorol(Dr. Reddy's) | 12,78-64 | |
| Ketorolac(various manufacturers) | 12,1-17 | |
| Active substance: Lornoxicam | ||
| Xefocam(Nycomedes) | 110-139 | It has a pronounced analgesic and anti-inflammatory effect. Indicated for short-term treatment of pain, including rheumatic diseases (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, etc.). It has many side effects and contraindications. |
| Xefokam Rapid(Nycomedes) | 192-376 | |
| Active substance: Aceclofenac | ||
| Aertal(Gideon Richter) | 577-935 | It has a good anti-inflammatory and analgesic effect. It contributes to a significant reduction in the severity of pain, morning stiffness, swelling of the joints, does not adversely affect cartilage tissue. It is used to reduce inflammation and pain in lumbago, toothache, rheumatoid arthritis, osteoarthritis and a number of other rheumatological diseases. Causes many side effects. Contraindications are similar to those of Panoxen. Do not use during pregnancy, lactation and in children under 18 years of age. |
| Active substance: Celecoxib | ||
| Celebrex(Pfizer, Searl) | 365,4-529 | One of the most selective (selectively acting) drugs of this group, which has a minimal negative effect on the gastrointestinal tract. Indications for use are symptomatic treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, back pain, bone and muscle pain, postoperative, menstrual and other types of pain. May cause swelling, dizziness, cough, and a number of other side effects. It has many contraindications for use, including class II-IV heart failure, clinically significant coronary heart disease, peripheral arterial disease and severe cerebrovascular disease. Not applicable during pregnancy, breastfeeding and under the age of 18 years. |
| Active substance: Etoricoxib | ||
| Arcoxia(Merck Sharp & Dome) | 317-576 | Potent selective drug. The mechanism of action, side effects and contraindications is similar to celecoxib. Indications for use are osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute gouty arthritis. |
| Active substance: Meloxicam | ||
| Amelotex(Sotex) | 52-117 | A modern selective drug with a pronounced anti-inflammatory effect. Indications for use are pain and inflammatory syndrome in osteoarthritis, osteochondrosis, rheumatoid arthritis and ankylosing spondylitis. It is not usually used for antipyretic purposes and for the treatment of other types of pain. It can cause a variety of side effects, but the negative effect on the gastrointestinal tract is less than that of non-selective drugs in this group. It has many contraindications, including pregnancy, lactation and children under 12 years of age. |
| Artrozan(Pharmstandard) | 87,7-98,7 | |
| Bi-xicam(Veropharm) | 35-112 | |
| Meloxicam(various manufacturers) | 9,5-12,3 | |
| Mirloks(Polfa) | 47-104 | |
| Movalis(Boehringer Ingelheim) | 418-709 | |
| Movasin(Synthesis) | 73,1-165 | |
Remember, self-medication is life-threatening, consult a doctor for advice on the use of any medications.
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