Active substance
Release form, composition and packaging
◊ Oral suspension (orange) orange in color with an orange smell; it is allowed to separate into a liquid layer and a precipitate, which, after mixing, form a homogeneous suspension.
Excipients: sodium carmellose - 0.97 g, macrogol glycerylhydroxystearate - 1.14 g, sucrose - 34.2 g, glycerol - 5.7 g, magnesium aluminum silicate (veegum) - 0.57 g, propylene glycol - 1.71 g, methyl parahydroxybenzoate - 0.15 g, propyl parahydroxybenzoate - 0.05 g, sodium phosphate dihydrate - 0.46 g, citric acid monohydrate - 0.91 g, sodium saccharinate - 0.25 g, crospovidone - 0.14 g, orange flavor - 0.34 g, sunset yellow dye (E110) - 0.02 g, purified water - up to 100 ml.
100 g - dark glass bottles (1) complete with a dosing spoon - packs of cardboard.
100 g - plastic bottles (1) complete with dosing syringe - cardboard packs
pharmachologic effect
NSAIDs. It has antipyretic, analgesic and anti-inflammatory effects.
The antipyretic effect is due to the blocking of COX-1 and COX-2 in the CNS arachidonic acid cascade, which leads to a decrease in the synthesis of prostaglandins, a decrease in their concentration in the cerebrospinal fluid and a decrease in the excitation of the thermoregulatory center. The effect of lowering the temperature during fever begins 30 minutes after taking the drug, its maximum effect is manifested after 3 hours.
The leading mechanism of analgesic action is a decrease in the production of prostaglandins of classes E, F and I, biogenic amines, which leads to the prevention of the development of hyperalgesia at the level of changes in the sensitivity of nociceptors. The analgesic effect is most pronounced in inflammatory pain.
The anti-inflammatory effect is due to inhibition of COX activity and a decrease in the synthesis of prostaglandins in inflammatory foci, which leads to a decrease in the secretion of inflammatory mediators, a decrease in the activity of the exudative and proliferative phases of the inflammatory process.
Like other NSAIDs, ibuprofen exhibits antiplatelet activity.
Pharmacokinetics
suction and r distribution
After oral administration, more than 80% of ibuprofen is absorbed from the gastrointestinal tract. C max in the blood when taken on an empty stomach - 45 minutes, when taken after a meal - 1.5-2.5 hours; in the synovial fluid - 2-3 hours, where higher concentrations are created than in the blood plasma. After absorption, about 60% of the pharmacologically inactive R-form of ibuprofen is slowly transformed into the active S-form.
Binding to plasma proteins (mainly with) is 90%.
Ibuprofen does not accumulate in the body.
Metabolism
Ibuprofen is biotransformed mainly in the liver.
It undergoes presystemic and postsystemic metabolism.
breeding
Ibuprofen has a two-phase elimination kinetics with T 1/2 2-2.5 hours. 60-90% of the drug is excreted by the kidneys in the form of metabolites and products of their conjugation with glucuronic acid, to a lesser extent, with bile and no more than 1% is excreted unchanged. After taking a single dose, the drug is completely eliminated within 24 hours.
Indications
The drug is intended only for the treatment of children.
Elevated body temperature of various origins with:
- colds;
- SARS, incl. flu
- angina (tonsillitis);
- childhood infections;
- post-vaccination reactions.
Pain syndrome of various origins of mild to moderate intensity with:
- toothache, painful teething;
- ear pain with inflammation of the middle ear;
- headache, migraine;
- neuralgia;
- Pain in the muscles, joints, due to injuries of the musculoskeletal system.
It is intended for symptomatic therapy, reducing pain and inflammation during the period of use, does not affect the progression of the disease.
Contraindications
- hypersensitivity to ibuprofen or other NSAIDs (including), as well as to auxiliary components of the drug;
- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (in
including in history);
- erosive and ulcerative diseases of the digestive tract (including peptic ulcer of the stomach and duodenum in the acute phase, ulcerative colitis, peptic ulcer, Crohn's disease - ulcerative colitis);
- severe renal insufficiency< 30 мл/мин), прогрессирующие заболевания почек;
- severe liver failure, active liver disease;
- confirmed hyperkalemia;
- inflammatory bowel disease;
- deficiency of sucrase / isomaltase;
- fructose intolerance, glucose-galactose malabsorption;
- blood clotting disorders (including hemophilia, prolongation of bleeding time, bleeding tendency, hemorrhagic diathesis);
- children's age up to 3 months.
Carefully: cirrhosis of the liver with portal hypertension; hepatic and / or renal failure; arterial hypertension, chronic insufficiency; nephrotic syndrome; hyperbilirubinemia; the presence of Helicobacter pylori infection; peptic ulcer of the stomach and duodenum (in history); gastritis; enteritis; colitis; blood diseases of unknown etiology (leukopenia and anemia); long-term use of NSAIDs; severe somatic diseases; simultaneous administration of oral corticosteroids (including prednisolone); anticoagulants (including warfarin); antiplatelet agents (including clopidogrel). Ibuprofen-Akrikhin contains sugar, so it should be used with caution in patients with diabetes.
Dosage
The drug is taken orally, after a meal. Before use, the vial should be shaken until a homogeneous suspension is obtained.
The dose is set depending on the age and body weight of the child.
For accurate dosing of the suspension, a dispenser (spoon or syringe) is attached to the vial.
A single dose is 5-10 mg / kg of body weight 3-4 times / day.
The maximum daily dose is 20-30 mg/kg of body weight.
Taking the drug in a single dose can be repeated every 6-8 hours. Do not exceed the maximum daily dose.
Infants from 3 to 6 months (5-7.6 kg)with post-vaccination reactions: 2.5 ml of the drug, if necessary - a second dose of 2.5 ml after 6 hours.
The daily dose of the drug for children from 3 to 6 months should not exceed 5 ml.
In children from 3 to 6 months, the drug can be used only after consultation with the attending physician.
Ibuprofen-Akrikhin can be used for no more than 3 days as an antipyretic and no more than 5 days as an anesthetic.
If the fever persists for more than 3 days, a doctor should be consulted.
If the pain syndrome persists for more than 5 days, you should consult your doctor.
Using the dispenser in syringe shape:
1. Unscrew the cap from the vial (press downwards and turn counterclockwise).
2. Press the dispenser firmly into the opening of the bottle neck.
3. Shake the vial vigorously.
4. To fill the dispenser, the bottle must be turned upside down, and then carefully move the dispenser piston down, pour the contents until the desired mark on the scale is reached.
5. Turn the vial over to its original position and carefully remove the dispenser from it with a twisting motion.
6. Place the tip of the dispenser in the child's mouth, and then, slowly pressing the piston, introduce the contents of the dispenser.
7. After use, the bottle should be closed by screwing the cap, and the dispenser should be rinsed with drinking water and dried.
Side effects
From the digestive system: NSAID-gastropathy (nausea, vomiting, loss of appetite, heartburn, abdominal pain, diarrhea, flatulence, pain and discomfort in the epigastric region); ulceration of the mucous membrane of the gums and the mucous membrane of the gastrointestinal tract (in some cases complicated by perforation and bleeding); dryness of the oral mucosa, aphthous stomatitis, pancreatitis, constipation, hepatitis.
From the respiratory system: shortness of breath, bronchospasm.
From the nervous system: headache, dizziness, sleep disturbance, anxiety, drowsiness, depression, psychomotor agitation, irritability, confusion, hallucinations; rarely - aseptic meningitis (more often in patients with autoimmune diseases).
From the sense organs: hearing loss, ringing or noise in the ears, reversible toxic optic neuritis, blurred vision or diplopia, impaired color vision, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic genesis), scotoma, amblyopia.
From the side of the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
From the side of the cardiovascular system: development or aggravation of heart failure, tachycardia, increased blood pressure.
From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: pruritus, skin rash (erythematous or urticaria), angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.
Others: increased sweating.
If any of the listed side effects occur, stop taking the drug and consult a doctor.
Overdose
Symptoms: abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, coma, hemorrhagic diathesis, decreased blood pressure, convulsions, respiratory arrest, acute renal failure, abnormal liver function, tachycardia, bradycardia, fibrillation atria. Children under the age of 5 are especially prone to sleep apnea, coma and seizures.
Serious consequences associated with the toxic effect of the drug usually appear after taking a dose exceeding 400 mg / kg of body weight. In case of overdose, you should immediately consult a doctor.
Treatment: gastric lavage (only within an hour after taking the drug), alkaline drinking, symptomatic therapy (correction of the acid-base state, blood pressure).
drug interaction
Do not use ibuprofen concomitantly with other NSAIDs. For example, acetylsalicylic acid reduces the anti-inflammatory effect of ibuprofen and enhances side effects.
If possible, the simultaneous use of ibuprofen and diuretics should be avoided, due to the weakening of the diuretic effect and the risk of developing renal failure.
Ibuprofen reduces the hypotensive activity of vasodilators (including ACE inhibitors).
Ibuprofen enhances the effect of oral hypoglycemic agents (especially sulfonylurea derivatives) and insulin.
Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions.
Antacids and cholestyramine reduce the absorption of ibuprofen.
Cefamandol, cefoperazone, cefotetan, plicamycin increase the incidence of hypoprothrombinemia.
Means with myelototic action increase the manifestations of hematotoxicity of the drug.
Cyclosporins, gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increase in nephrotoxicity.
Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.
Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen.
Enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (increased risk of hemorrhagic complications).
Increases the blood concentration of digoxin, methotrexate and lithium preparations.
Caffeine enhances the analgesic effect of ibuprofen.
special instructions
In patients with bronchial asthma or other diseases that occur with bronchospasm, ibuprofen may increase the risk of developing bronchospasm. The use of the drug in these patients is permissible only if great care is taken, and in case of difficulty in breathing, you should immediately consult a doctor.
During long-term treatment with NSAIDs, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys.
To prevent the development of NSAID gastropathy, it is recommended to combine it with prostaglandin E preparations (misoprostol). When symptoms of NSAID gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a blood test to determine hemoglobin, hematocrit, and a fecal occult blood test.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
To reduce the risk of developing adverse effects on the part of the gastrointestinal tract, Ibuprofen-Akrikhin should be used at the minimum effective dose for the shortest possible course.
1 ml of suspension of the drug Ibuprofen-Akrikhin contains about 0.34 g of sucrose, which corresponds to approximately 0.03 XE. Thus, the minimum single dose of the drug, equal to 2.5 ml, contains 0.85 g of sucrose (corresponding to 0.075 XE); the maximum single dose of the drug, equal to 15 ml, contains 5.13 g of sucrose (corresponding to 0.45 XE)
Influence on the ability to drive vehicles and control mechanisms
Given the possibility of developing significant side effects, during the period of treatment, care must be taken when driving vehicles and engaging in potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.
For impaired liver function
The drug is contraindicated in severe liver dysfunction.
Terms of dispensing from pharmacies
The drug is approved for use as a means of OTC.
Terms and conditions of storage
The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25°C. Shelf life - 3 years.
An opened vial should be used within 6 months.
Ibufen is a modern antipyretic and analgesic drug based on Ibuprofen, which can alleviate the condition of a sick adult or child in 30 minutes.
Therapists and pediatricians without fear prescribe this medication to their large and small patients as part of the complex therapy of influenza, tonsillitis, SARS, pain in the joints, bones and muscles.
On this page you will find all the information about Ibufen: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Ibufen. Want to leave your opinion? Please write in the comments.
Clinical and pharmacological group
Terms of dispensing from pharmacies
Released without a prescription.
Prices
How much does Ibufen cost? The average price in pharmacies is at the level of 80 rubles.
Release form and composition
At the moment, the pharmacological agent has several forms of release. Among them:
- Ibufen D is a syrup for oral use. A 120 ml plastic bottle is used as packaging. The content of ibuprofen is 100 mg per 5 ml of solution. A special syringe is attached as a dispenser;
- Ibufen for children comes in the form of 200 mg tablets. Available in blisters of 10 or 20 tablets each. The packaging must be marked that the drug is intended for children;
- Ibufen Forte is an oral suspension of enhanced action. The content of ibuprofen is 200 mg per 5 ml of solution. The syrup is available in a 100 ml plastic bottle;
- oral suspension. Produced in bottles of 100 ml each with a measuring spoon included. The syrup has a citrus smell and a sweetish aftertaste. Before use, the drug should be shaken;
- Ibufen Ultra is an enhanced form of release of the drug in the form of blue capsules. The concentration of Ibuprofen is 200 mg in one capsule. Packages are available in which there are 1 or 2 blisters. Each contains 10 capsules.
Pharmacological effect
The main active ingredient of the drug - ibuprofen - has an anti-inflammatory, as well as antipyretic and analgesic effect on the human body (the latter is most pronounced with pain of an inflammatory nature of origin).
The mechanism of action of the drug is due to the ability of ibuprofen to have an inhibitory effect on the synthesis of prostaglandins by inhibiting cyclooxygenase, an enzyme that plays an important role in the metabolism of arachidonic acid and the formation of prostaglandins. And this, in turn, leads to inhibition of the severity of the inflammatory process, a decrease in elevated body temperature and the generation of pain impulses along the nerve structures.
Indications for use
According to the instructions, Ibufen is intended for use in:
- The presence of an inflammatory process in the small pelvis, including during childbirth (in these cases, Ibufen is used as a tocolytic (preventing premature birth) and pain reliever);
- Feverish syndrome caused by infectious and catarrhal diseases;
- Pain syndrome: with myalgia, radiculitis, arthritis, dental and headache (including those caused by menstrual syndrome) pain, ossalgia, arthralgia, myalgia, neuralgia, tendovaginitis, tendinitis, bursitis, neuralgic amyotrophy, oncological pain, postoperative and post-traumatic pain, if they accompanied by inflammation
- Inflammatory and degenerative diseases of the musculoskeletal system, such as: osteochondrosis, psoriatic, rheumatoid and chronic juvenile arthritis, Parsonage-Turner disease (or neuralgic amyotrophy), arthritis caused by systemic lupus erythematosus (as one of the complex therapy drugs), ankylosing spondylitis ( or ankylosing spondylitis), gouty arthritis.
Contraindications
Ibufen is contraindicated in:
- nasal polyps;
- hearing loss;
- Hemophilia, hemorrhagic diathesis or other blood clotting disorder;
- Deficiency of glucose-6-phosphate dehydrogenase;
- Exacerbation of peptic ulcer of the stomach or duodenum;
- angioedema;
- Severe violations of the liver / kidney function;
- Known hypersensitivity to ibuprofen, acetylsalicylic acid (ASA) or any other NSAID;
- Hypersensitivity to any auxiliary component;
- A history of a case of bronchospasm after taking ASA or another NSAID.
The drug is contraindicated in children under 6 months of age or weighing less than 7 kg. Children aged 6-12 months can only be given Ibufen if prescribed by a doctor.
It is possible to use the drug, but under close medical supervision with:
- Dyslipidemia;
- Ischemic heart disease;
- Presence of Helicobacter pylori infection;
- Hyperbilirubinemia;
- Severe somatic diseases;
- Liver/renal failure;
- Leukopenia, anemia;
- The need for long-term use of the drug;
- Diseases of peripheral arteries;
- diabetes mellitus.
- Severe heart failure.
- arterial hypertension;
- Peptic ulcer of the stomach and duodenum in history;
- nephrotic syndrome;
- Obstructive lung diseases and bronchial asthma;
- Cerebrovascular diseases;
- Cirrhosis of the liver with portal hypertension.
With extreme caution, Ibufen is also prescribed to elderly patients, people who abuse alcohol and / or smoke.
Use during pregnancy and lactation
The use of Ibufen is contraindicated in the third trimester of pregnancy.
There are no studies on the effect of Ibufen during breastfeeding. However, if there is a need for its use, breastfeeding should be stopped for the period of taking the drug.
Instructions for use
The instructions for use indicate that Ibufen Forte, Ibufen D, as well as simple Ibufen - the average single dose for adults is 5-10 mg per 1 kg of body weight, repeated 3-4 times during the day. The maximum daily amount of the drug taken should not exceed 30 mg per 1 kg of the patient's weight. The course of conservative therapy is prescribed individually by the attending physician, as it must be consistent with the indications for treatment and regular diagnostic indicators of the body.
Ibufen Suspension is taken by mouth (by mouth) after a meal. Dosage depends on age:
- Children aged six months to 1 year - 2.5 ml (50 mg ibuprofen) 3 times a day, not more than 7.5 ml.
- Children aged 1 to 3 years - 2.5 ml 3-4 times a day, depending on the severity of pain, temperature or inflammatory changes. Not more than 10 ml.
- Children aged 3 to 6 years - 5 ml (100 mg ibuprofen) 3 times a day, the maximum dose during the day should not exceed 15 ml.
- Children aged 6 to 9 years - 5 ml 4 times a day, no more than 20 ml per day.
- Children aged 9 to 12 years - 10 ml 3 times a day, no more than 30 ml of suspension per knock.
- Children over the age of 12 years - 10 ml 4 times a day (no more than 20 ml per day).
Usually, the suspension is taken every 6-8 hours during the day. Do not exceed the maximum allowable daily dose. For children aged 6 months to 1 year, the drug can be used only as directed by a doctor.
Side effects
With conservative treatment with Ibufen, the following undesirable consequences may occur:
- From the hematopoietic system: heart failure, tachycardia, thrombocytopenia, anemia, increased blood pressure, leukopenia (manifested as agranulocytosis).
- From the side of the central nervous system: dizziness, headache, sleep disturbance, anxiety, drowsiness, depression, reversible toxic amblyopia, blurred vision, diplopia - double vision.
- Urinary system: acute renal failure, nephrotic syndrome, which is manifested mainly by edema, polyuria, cystitis, inflammation of the renal apparatus.
- Digestive system: dyspeptic indigestion, diarrhea, loss of appetite, heartburn, constipation, flatulence, impaired excretory function of the liver, peptic ulcers of the stomach with hemorrhagic outcome.
- Allergic reactions: skin itching and rash, bronchospastic syndrome, rhinitis, Quincke's angioedema, Stevens-Johnson and Lyell's syndrome.
Overdose
A significant excess of the age recommended therapeutic dose of Ibufen suspension leads to the development of abdominal pain, nausea, vomiting, headache, tinnitus, drowsiness, bleeding of various localization and intensity. In this case, the stomach, intestines are washed, activated charcoal or other intestinal sorbents are taken, as well as symptomatic therapy. There is no specific antidote for ibuprofen.
special instructions
- Patients referred for 17-ketosteroid testing should discontinue ibuprofen within 48 hours.
- With prolonged use of Ibufen, it is necessary to monitor the picture of peripheral blood, the functional state of the kidneys and liver.
- To reduce the risk of gastrointestinal side effects, Ibufen should be taken at the lowest effective dose for the shortest possible period.
- To prevent the development of NSAID gastropathy, Ibufen is recommended to be combined with prostaglandin E preparations (for example, misoprostol). When symptoms of the disease appear, careful monitoring of the patient's condition is necessary, including a fecal occult blood test, a blood test with the determination of hemoglobin and hematocrit, and esophagogastroduodenoscopy.
- In bronchial asthma or other diseases that may be accompanied by bronchospasm, ibuprofen can cause the development of bronchospasm. For this reason, the drug should be used only with great caution in these patients. In case of difficulty breathing, you should immediately consult a doctor.
- Patients with diabetes should take into account that 1 ml of suspension contains about 0.34 g of sucrose, or about 0.03 XE. Thus, the minimum single dose of Ibufen (2.5 ml) contains 0.85 g of sucrose (0.075 XE), the maximum single dose (15 ml) contains 5.13 g of sucrose (0.45 XE).
Painkillers and antipyretics are the most popular types of drugs in the pharmacological market. Millions of people need these funds every day. Some drugs are needed to relieve a headache or toothache, others use them to eliminate the symptoms of viral diseases. Some people have to take these drugs throughout their lives. Modern drug manufacturers produce a variety of tablets, capsules, suspensions. Ibuprofen-based drugs are very popular. This component is included in the preparation "Ibufen Ultra". Instructions and features of its use will be described for you today.
Foreword
Pain is a natural reaction of the human body to a stimulus of nerve endings. It can be caused by various reasons. able to block this unpleasant feeling. It is important to take the funds correctly. Most home first aid kits contain different types of painkillers. Some have a relaxing effect on smooth muscles, relieve spasm. Others inhibit the synthesis of certain enzymes.
Most pain relievers are sold without a prescription. This allows the patient to use the medicine on their own in the event of disturbing symptoms. It is believed that the drug "Ibufen Ultra" is not only effective, but also safe. Is it really? It is worth learning about this tool in more detail before using it.
Composition and description
Tablets "Ibufen Ultra" instruction positions as an anti-inflammatory, analgesic, which also helps to reduce elevated body temperature. Each capsule contains 200 mg of the active ingredient, which is ibuprofen. The drug is produced with the addition of minor substances: macrogol, potassium hydroxide and water. Each pill is coated with a gelatin shell, which allows you to deliver the original composition to the stomach.
The drug is sold in 10 or 20 blue capsules per package (1 or 2 blisters, respectively). The trade name is indicated on the pack in large letters: "Ibufen Ultra". The instruction is attached to each unit of the drug. In the pharmacy, you can also purchase the Ibufen Ultra suspension, which is more often used for children.
The effectiveness of the drug
How does Ibufen Ultra work? The instruction says that the active substance is found in the maximum amount within an hour after taking the pill. If you use the drug during meals, then this interval can double. Ibuprofen penetrates into tissues and joints, helps to reduce vascular permeability. The drug blocks the synthesis of prostaglandins, which contributes to the anti-inflammatory effect. The antipyretic effect occurs on average 30-45 minutes after taking the pill, and the analgesic effect occurs after 10-20 minutes. The effectiveness of the drug lasts for 8-12 hours, but in some cases it may be less or more.
Who is assigned "Ibufen Ultra"?
Instructions for use recommends the drug for emergency use for pain and fever. The manufacturer allows self-administration of tablets, but still recommends that you first consult a doctor. If you read the annotation, you can find out that the medicine helps to cope with the following problems:
- febrile syndrome caused by various causes (viral or bacterial disease, colds, vaccination, poisoning, intoxication);
- pain (tooth, headache, articular, caused by trauma);
- periodic ailments in women;
- inflammatory processes in the body.
Usage restrictions
Despite the fact that Ibufen Ultra is positioned as a safe drug for use, the drug has its own contraindications. You can not use the drug under the following circumstances:
- high sensitivity to ibuprofen;
- intolerance to non-steroidal anti-inflammatory drugs;
- acetylsalicylic acid;
- an ulcer of the intestine or stomach in an acute form;
- kidney or liver failure;
- blood diseases;
- pregnancy in the 1st and 3rd trimesters;
- children's age up to 6 years.
"Ibufen ultra": instructions
For children and adults, the medication is prescribed for the purpose of internal use. The capsule should be washed down with clean water. The tablet is not pre-opened or chewed. To accelerate the effect of the drug, it is advisable to take it at the beginning of a meal or 1-2 hours after it. If you use the drug during a meal, it may act more slowly.
Adult patients and children over 12 years of age should take Ibufen Ultra 200 mg. The instruction allows the use of a double dose (400 mg). The daily volume of the drug should not exceed 1200 mg, which is equivalent to six tablets. Repeated administration of the drug is carried out no earlier than 4 hours after the first use.
The duration of use of anesthetic capsules should not exceed five days. If the medicine is taken to reduce body temperature, then therapy can be carried out for only three days. Lack of improvement after the specified time obliges the consumer to consult a doctor.
Adverse reactions and consequences of an overdose of the drug
What happens if you use large doses of Ibufen Ultra (tablets)? Instructions for use warns the consumer against this, indicating the daily and one-time rate. With an overdose of the drug, there is a decrease in blood pressure, lethargy, drowsiness. The patient may lose consciousness and fall into a coma. Poisoning with high doses of the drug is accompanied by nausea, vomiting, diarrhea and other symptoms of intoxication. In case of overdose, it is imperative to consult a doctor for action. It is permissible to induce vomiting on your own (if the drug has been taken recently) and use a sorbent.
Tablets "Ibufen ultra" - the instruction says - are usually well tolerated. In rare cases, they can cause an unpleasant reaction called a side effect. It is necessary to consult a doctor if the following symptoms appear after taking the drug:
- nausea, heartburn, abdominal pain, upset stool and other intestinal manifestations;
- headache, drowsiness or agitation;
- changes in blood pressure;
- allergies (swelling, rash, itching, urticaria).
The drug can affect the state of the blood. It is quite difficult to notice these changes on your own. Therefore, in case of any kind of deterioration in well-being, you should consult a doctor.
Possibility of use with other drugs
The drug "Ibufen ultra 200" instructions for use allows you to use it simultaneously with other drugs. However, taking certain medications with pain medication may not affect the patient's well-being as expected. The instructions describe the features of complex therapy. Before using other medications, be sure to read this paragraph.
- The simultaneous use of acetylsalicylic acid and other types of NSAIDs increases the likelihood of a negative reaction from the digestive system.
- Diuretic and laxative formulations reduce the effectiveness of antipyretic drugs, reduce their anti-inflammatory effect.
- Ibufen Ultra capsules should be used with caution along with anticoagulants. When combined, these agents increase the chance of bleeding.
- It should not be used together with drugs containing lithium, as its content in the body increases.
- Steroid drugs taken with Ibufen Ultra increase the likelihood of side effects of the latter.
- Antacids reduce the absorption efficiency of the active substance of Ibufen Ultra capsules.
The use of the drug along with caffeinated drinks enhances the analgesic effect. In combination with alcohol, the toxic effect on the liver increases.
additional information
There are separate groups of patients who need to consult a doctor before using the drug. This includes:
- lactating women;
- people with any diseases of the liver and kidneys;
- children under 12;
- allergy sufferers;
- patients with bronchial asthma;
- ulcers;
- hypertension.
If you need to take Ibufen Ultra for a long time, then you need to periodically monitor blood counts.
Doctors about the drug
Doctors strongly recommend: before using the drug "Ibufen Ultra" (capsules), the instructions should be studied by each consumer. Doctors say that this medication is proven and safe. It is used most often. It has even less negative effect on the liver than the famous Paracetamol. Experts warn that the drug increases the risk of bleeding. Therefore, you should not use this tool before surgery. Even if you have a conventional tooth extraction, give preference to other analgesics. Doctors do not recommend taking medicine when it comes to abdominal pain. Of course, the drug will help alleviate the condition. But this makes it difficult to make a correct diagnosis. A blurred clinical picture will not allow doctors to provide the necessary assistance to the patient in time.
What are consumers saying?
Most of the patients who once had to use the Ibufen Ultra product leave positive feedback about it. The medication - people say - effectively helps to cope with painful sensations. Use an anesthetic for women during menstruation. It allows you not to change the usual way of life and to conduct labor activities. You can hear reviews about the drug that report its weak effect. Patients report taking medication to reduce fever. At the same time, the capsules helped, but not quite. That is, the thermometer values decreased by 1-1.5 degrees, but did not return to normal.
The manufacturer does not recommend deviating from the application standards prescribed in the instructions. But some patients manage to take the medicine on their own terms. There are cases when parents gave capsules to children under 12 years old. However, they did not notice any negative reactions. The product did its job well. Newly minted mothers said that they had to take Ibufen Ultra during pregnancy. They had no bleeding or other consequences.
Alternative means
It is not uncommon for a patient to need a drug change. Analogues, you can choose structural and drugs that are similar in action. Absolute substitutes include all drugs that contain the active ingredient ibuprofen. The most popular today is the drug "Nurofen". It is available in different forms: tablets, capsules, suppositories, suspension. This medicine is prescribed to children from the age of three months. Other alternative remedies are less popular, but no less effective: Advil, Mig, Brufen, and so on.
If a patient is allergic to ibuprofen, it is advisable to replace it with another drug that has a similar effect. An analgesic and antipyretic effect can be obtained by using drugs: Paracetamol, Panadol, Analgin, Next, Baralgin, Pentalgin, Nise, Nimulid, Ketonol and many others. Each pharmacist can choose a replacement for Ibufen Ultra. But it is better to consult a doctor before using any other medication.
Let's summarize
Today you learned what the instructions for use tell the consumer about the drug "Ibufen Ultra". Capsules are also presented to your review (photo). Everyone sooner or later needs the use of antipyretics. The reviews that are formed afterwards can be good or bad. Don't blindly rely on them. The same medicine has different efficacy in different diseases. In order for the drug to really help, and its use to be safe, you need to consult a doctor and get individual prescriptions. Good health, live without pain!
Instructions for medical use
medicinal product
IBUFEN ® ULTRA
Tradename
Ibufen ® Ultra
International non-proprietary name
ibuprofen
Dosage form
Capsules 200 mg
Compound
One capsule contains
active substance - ibuprofen 200 mg,
Excipients: macrogol 600, potassium hydroxide, purified water,
shell: liquid sorbitol, non-crystallizing, liquid maltitol, patent blue E131, gelatin.
Description
Oval-shaped gelatin capsules with a translucent blue shell containing a viscous liquid
Pharmacotherapeutic group
Non-steroidal anti-inflammatory drugs. Propionic acid derivatives
ATC code М01АЕ01
Pharmacological properties
Pharmacokinetics
After oral administration, more than 80% of ibuprofen is absorbed from the digestive tract. 90% of the drug binds to plasma proteins (mainly albumin).
The period of reaching the maximum concentration in the blood plasma when taken on an empty stomach is 45 minutes, when taken after a meal - 1.5-2.5 hours; in the synovial fluid - 2-3 hours, where higher concentrations are created than in the blood plasma.
The drug does not accumulate in the body.
Ibuprofen is metabolized mainly in the liver. It undergoes presystemic and postsystemic metabolism. After absorption, about 60% of the pharmacologically inactive R-form of ibuprofen is slowly transformed into the active S-form.
60-90% of the drug is excreted by the kidneys in the form of metabolites and products of their combination with glucuronic acid, to a lesser extent, with bile and no more than 1% is excreted unchanged. After taking a single dose, the drug is completely eliminated within 24 hours.
Pharmacodynamics
Ibufen ® Ultra is a propionic acid derivative. It has analgesic, antipyretic and anti-inflammatory effects.
The mechanism of action of Ibufen ® Ultra is primarily due to the suppression of prostaglandin biosynthesis by reducing the activity of cyclooxygenase (COX) - an enzyme that regulates the conversion of arachidonic acid into prostaglandins, prostacyclin and thromboxane. At the same time, as a result of irreversible inhibition of the cyclooxygenase pathway of arachidonic acid metabolism, the formation of prostaglandins decreases. A decrease in the concentration of prostaglandins at the site of inflammation is accompanied by a decrease in the formation of bradykinin, endogenous pyrogens, other biologically active substances, oxygen radicals and NO. All this leads to a decrease in the activity of the inflammatory process (anti-inflammatory effect of ibuprofen) and is accompanied by a decrease in pain reception (analgesic effect). A decrease in the concentration of prostaglandins in the cerebrospinal fluid leads to the normalization of body temperature (antipyretic effect).
Ibufen ® Ultra soft gelatin capsules contain liquid ibuprofen. The gelatin capsule ensures high dosing accuracy of the substances placed in them. The capsule shell provides protection of the active substance from light, air and moisture, and also eliminates the unpleasant taste and smell of the medicinal substance when taken. The capsule disintegrates in the gastrointestinal tract faster than dragees and tablets, and its liquid contents are absorbed faster and more easily in the human body, providing high bioavailability of ibuprofen.
Indications for use
Elevated body temperature of various origins with:
Colds
Acute respiratory viral infections (tonsillitis, pharyngitis)
Childhood infections accompanied by fever
Pain syndrome of various origins of mild to moderate intensity with:
Ear pain due to inflammation of the middle ear
Toothache, painful teething
Headache, migraine
Painful periods
neuralgia
Rheumatic pains
Pain in muscles, joints
Injuries of the musculoskeletal system.
Dosage and administration
Applied inside. capsule must be swallowed entirely, drinking a small amount water. 1-2 capsules every 4-6 hours. The maximum daily dose is 6 capsules (1200 mg ibuprofen).
The minimum interval between successive doses is 4-6 hours.
The drug should not be used for more than 4 days as an anesthetic and for more than 3 days as an antipyretic without medical supervision.
Side effects
Depending on the frequency of occurrence, the following groups of side effects are distinguished:
Often (>1/100, <1/10 )
Nausea, vomiting, heartburn, diarrhea, abdominal pain, flatulence, constipation
Hoften (>1/1000, <1/100 )
Nausea, heartburn, diarrhea, abdominal pain
Headache, dizziness, agitation, insomnia, irritability, fatigue, depression, confusion, hallucinations
visual impairment
Skin rash, itching, urticaria
Rcaustically(>1/10000, <1/1000 )
Noise in ears
Impaired liver and kidney function
Overy rarely(<1/10000 )
Erosive and ulcerative lesions of the gastrointestinal tract, dry mouth, ulcerative stomatitis, acute colitis, Crohn's disease, endogastritis, hepatitis, pancreatitis, liver dysfunction
Hypertension
Tachycardia, heart failure, myocardial infarction, stroke
Esophagitis, pancreatitis, formation of diaphragmatic narrowing of the intestine
Acute renal failure, nephrotic syndrome, allergic nephritis, polyuria, cystitis
Anemia (including hemolytic, aplastic), thrombocytopenia and
thrombocytopenic purpura, agranulocytosis, leukopenia
Psychotic reactions, depression
Quincke's edema, angioedema, anaphylactoid reactions,
anaphylactic shock, bronchospasm, fever, multiforme
exudative erythema (including Stevens-Johnson syndrome),
toxic epidermal necrolysis (Lyell's syndrome), eosinophilia,
allergic rhinitis
Reversible toxic optic neuritis, blurred vision, diplopia, conjunctivitis
Increased sweating
Bleeding (gastrointestinal, gingival, uterine, hemorrhoidal)
Aseptic meningitis
Contraindications
Hypersensitivity to ibuprofen or other ingredients
drug, as well as to other non-steroidal anti-inflammatory
medicines
Any previous manifestations of allergy symptoms in the form of a runny nose, skin
rashes or bronchospastic reactions after application
acetylsalicylic acid or other nonsteroidal
anti-inflammatory drugs
Peptic ulcer of the stomach and duodenum in the acute phase
Gastrointestinal bleeding
severe heart failure
Severe liver and kidney failure
Glucose-6-phosphate dehydrogenase deficiency
Blood diseases (hemophilia, hypocoagulation, hemorrhagic diathesis)
Pregnancy and lactation.
Children and adolescents up to 18 years of age.
Drug Interactions
Ibufen ® Ultra(as well as other drugs of the group of non-steroidal anti-inflammatory drugs) should not be used simultaneously with the following drugs:
acetylsalicylic acid or other non-steroidal anti-inflammatory drugs - the risk of side effects from the gastrointestinal tract increases,
antihypertensive drugs and diuretics - drugs from the group of non-steroidal anti-inflammatory drugs can cause a decrease in the effectiveness of these drugs,
anticoagulants - few clinical data indicate that non-steroidal anti-inflammatory drugs can increase the effect of drugs that reduce blood clotting, digoxin, phenytoin, lithium and methotrexate - it has been proven that non-steroidal anti-inflammatory drugs can cause an increase in plasma concentrations of these drugs. There is evidence of an increase in bleeding time in patients taking ibuprofen and zidovudine simultaneously, mineralocorticoids, glucocorticoids increase side effects, sulfonylurea derivatives increase the hypoglycemic effect, antacids and cholestyramine reduce absorption, caffeine enhances the analgesic effect.
As a result of taking with cyclosporine, toxic effects on the kidneys increase. Medicines containing probenecid or sulfinpyrazone may delay the elimination of ibuprofen. Simultaneous use of Ibufen® Ultra and potassium-sparing diuretics can lead to hyperkalemia (it is recommended to carry out the concentration of potassium in the blood serum). NSAIDs can weaken the action of Mefiprestone, you should refrain from using NSAIDs for 8-12 days after using Mefiprestone. With the simultaneous use of Tacrolimus and Ibufen® Ultra, the risk of nephrotoxicity increases.
Simultaneous use of Ibufen® Ultra and alcohol side effects of the drug on the part of the gastrointestinal tract and central nervous system may increase.
special instructions
Before taking Ibufen ® Ultra, you should consult your doctor if you have previously confirmed: bronchial asthma, urticaria,
diseases of the liver and kidneys, peptic ulcer of the stomach and duodenum in the history of arterial hypertension.
During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, complete blood count (hemoglobin determination), fecal occult blood analysis. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Patients with uncontrolled blood pressure, circulatory failure and coronary heart disease should be prescribed Ibufen® Ultra with caution.
Patients with rare genetic fructose intolerance should not take Ibufen® Ultra due to its maltitol content.
Features inliyangdrug namethe ability to drive vehicles andpotentially dangerous mechanisms
When taking Ibufen® Ultra, you should refrain from driving and servicing machinery.
Overdose
Symptoms: abdominal pain, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, coma, hemorrhagic diathesis, decreased blood pressure, convulsions, acute renal failure, liver dysfunction, tachycardia, bradycardia.
Treatment: activated charcoal, symptomatic therapy.
Release form and packaging
10 capsules are placed in a blister pack made of polyvinyl chloride / polyvinyl dichloride (PVDC / PVC) film and aluminum foil.
1 or 2 contour packs, together with instructions for medical use in the state and Russian languages, are placed in a cardboard box.
Storage conditions
Store in original packaging at a temperature not exceeding 25 0 С.
Keep out of the reach of children.
Shelf life
Do not use the drug after the expiration date.
Terms of dispensing from pharmacies
On prescription
Manufacturer
"Medana Pharma" JSC
98-200 Sieradz, st. V. Loketka 10, Poland
Registration certificate holder
Chimpharm JSC, Kazakhstan
Address of the organization hosting on the territory of the Republic of Kazakhstan claims from consumers on the quality of products (goods)
JSC "Khimfarm", Shymkent, REPUBLIC OF KAZAKHSTAN,
st. Rashidova, b / n, tel / f: 560882
Phone number 7252 (561342)
Fax number 7252 (561342)
E-mail address [email protected]
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Instructions for the medical use of the drug
Description of the pharmacological action
Blocks arachidonic acid cyclooxygenase, and reduces the synthesis of PG.
Indications for use
As an antipyretic: for colds, acute respiratory viral infections, influenza, tonsillitis (pharyngitis), childhood infections accompanied by fever, post-vaccination reactions.
As an analgesic: for toothache, painful teething, headache, migraine, neuralgia, pain in muscles, joints, injuries and burns.
Release form
Suspension for oral administration 100 mg/5 ml; dark glass bottle (flacon) 100 g with measuring spoon (spoon) cardboard pack 1;
Suspension for oral administration 100 mg/5 ml; barrel (barrel) polyethylene (th) 120 l;
Suspension for oral administration 100 mg/5 ml; bottle (bottle) plastic 100 g with dosing syringe cardboard pack 1;
Pharmacodynamics
Antipyretic, analgesic, anti-inflammatory.
Blocks arachidonic acid cyclooxygenase, and reduces the synthesis of PG.
The antipyretic effect is due to a decrease in the concentration of PG in the cerebrospinal fluid, a decrease in the excitation of the thermoregulatory center, which results in the normalization of body temperature.
The analgesic effect is associated with a decrease in the production of PG classes E, F, I, biogenic amines, a change in the sensitivity of nociceptors and the prevention of the development of hyperalgesia.
The analgesic effect is most pronounced with inflammatory pain.
The anti-inflammatory effect is due to a decrease in the secretion of inflammatory mediators and a decrease in the activity of the exudative and proliferative phases of the inflammatory process.
The antipyretic and analgesic effect appears earlier and at lower doses than the anti-inflammatory effect, which occurs on the 5-7th day of treatment.
Pharmacokinetics
After oral administration, more than 80% is absorbed from the gastrointestinal tract. Cmax in plasma is achieved when taken on an empty stomach - after 45 minutes, when taken after meals after 1.5-2.5 hours. Protein binding - 90%.
It slowly penetrates into the joint cavity, but in the synovial fluid it creates concentrations greater than in the blood plasma (Cmax in the synovial fluid is reached after 2-3 hours).
Metabolized mainly in the liver. It undergoes pre- and post-systemic metabolism.
After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form.
Excreted by the kidneys (60-90% in the form of metabolites and products of their combination with glucuronic acid, to a lesser extent - with bile, unchanged - no more than 1%).
It has a two-phase elimination kinetics with a T1 / 2 of 2-2.5 hours, after administration in a single dose it is completely eliminated within 24 hours.
The antipyretic effect of Ibufen develops after 30 minutes and lasts 6-8 hours.
Use during pregnancy
Contraindicated in the III trimester of pregnancy, in the I and II trimester - with caution.
At the time of treatment should stop breastfeeding.
Contraindications for use
Hypersensitivity (including to acetylsalicylic acid or other NSAIDs), peptic ulcer of the stomach and duodenum, severe insufficiency of the liver, kidneys, cardiovascular system, arterial hypertension, hemophilia, hypocoagulation, hemorrhagic diathesis, glucose-6-phosphate dehydrogenase deficiency , bronchospastic reactions after the use of acetylsalicylic acid or other NSAIDs ("aspirin asthma"), Quincke's edema, nasal polyps, hearing loss, infancy (up to 6 months, with body weight below 7 kg).
Side effects
From the side of the central nervous system: headache, dizziness, sleep disturbance, anxiety, drowsiness, depression, agitation, visual impairment (reversible toxic amblyopia, blurred vision or double vision).
On the part of the hematopoietic organs: heart failure, tachycardia, increased blood pressure; anemia, thrombocytopenia, agranulocytosis, leukopenia.
From the digestive tract: nausea, vomiting, loss of appetite, heartburn, abdominal pain, diarrhea, constipation, flatulence, liver dysfunction, peptic ulcers, gastric bleeding.
From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: itching, rash, bronchospastic syndrome, allergic rhinitis, angioedema, Steven-Johnson syndrome, Lyell's syndrome.
Dosage and administration
Inside, after eating. The average single dose is 5–10 mg/kg of body weight 3–4 times a day.
Children aged
6 months - 1 year (7–9 kg) - 2.5 ml (50 mg) 3 times a day, the maximum daily dose is 7.5 ml (150 mg).
1-3 years (10-15 kg) - 2.5 ml (50 mg) 3-4 times a day, the maximum daily dose is 7.5-10 ml (150-200 mg).
3-6 years (16-20 kg) - 5 ml (100 mg) 3 times a day, the maximum daily dose is 15 ml (300 mg).
6-9 years (21-30 kg) - 5 ml (100 mg) 4 times a day, the maximum daily dose is 20 ml (400 mg).
9-12 years (31-41 kg) - 10 ml (200 mg) 3 times a day, the maximum daily dose is 30 ml (600 mg).
Over 12 years old (more than 41 kg) - 10 ml (200 mg) 4 times a day, the maximum daily dose is 40 ml (800 mg).
The dose can be repeated every 6-8 hours. Do not exceed the maximum daily dose.
For children from 6 months to 1 year, the drug is prescribed on the recommendation of a doctor.
Overdose
Symptoms: abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, hemorrhagic diathesis, decreased blood pressure, acute renal failure, abnormal liver function, tachycardia, bradycardia, atrial fibrillation; convulsions, apnea and coma (especially characteristic of children under 5 years of age).
Treatment: gastric lavage, administration of activated charcoal, alkaline drink, symptomatic therapy (correction of acid-base balance, blood pressure).
Interactions with other drugs
The simultaneous use of two or more NSAIDs should be avoided due to an increased risk of side effects. With the simultaneous use of ibuprofen, it reduces the anti-inflammatory and antiaggregatory effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving low doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen). When used with thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases at the same time. Ibuprofen enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics.
Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Microsomal oxidation inhibitors reduce the risk of hepatotoxicity.
Antacids and cholestyramine reduce the absorption of ibuprofen. Caffeine enhances the analgesic effect of ibuprofen. Cefamandol, cefoperazone, cefotetan, valproic acid increase the incidence of hypoprothrombinemia.
Myelotoxic drugs increase the manifestations of ibuprofen hematotoxicity. Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of PG in the kidneys, which is manifested by an increase in nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen.
Ibuprofen reduces the effect of antihypertensive drugs (including CCBs and ACE inhibitors), the natriuretic and diuretic activity of furosemide and hydrochlorothiazide, and the effectiveness of uricosuric drugs. Enhances the side effects of mineralocorticoids, glucocorticoids, estrogens, ethanol. Enhances the effect of oral hypoglycemic drugs and insulin. Increases the concentration in the blood of digoxin, lithium preparations and methotrexate. Ibuprofen may reduce the clearance of aminoglycosides (with simultaneous administration, the risk of nephrotoxicity and ototoxicity may increase).
Precautions for use
Caution should be taken with cirrhosis of the liver with portal hypertension, liver and / or kidney failure, heart failure, nephrotic syndrome, hyperbilirubinemia, peptic ulcer of the stomach and duodenum (in history), gastritis, enteritis, colitis, blood diseases (leukopenia, anemia) , pregnancy (II-III trimesters), during breastfeeding. In patients with bronchial asthma or other diseases that occur with bronchospasm, there may be an increased risk of developing bronchospasm.
During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated (conducting esophagogastroduodenoscopy, a blood test with the determination of hemoglobin, hematocrit, fecal occult blood analysis).
In the absence of an antipyretic effect within 2 days and an analgesic effect within 3 days, you should consult a doctor. In case of side effects, stop taking the drug and consult a doctor.
Special instructions for admission
Shake the bottle before use until a homogeneous suspension is obtained. With prolonged use, NSAIDs can cause damage to the gastric mucosa, peptic ulcers, and gastrointestinal bleeding.
Patients with diabetes take with caution - contains sugar.
In case of side effects, stop taking the drug and consult a doctor.
Storage conditions
In a dry, dark place, at a temperature of 15–25 °C.
Shelf life
Belonging to ATX-classification:
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